Host Cell Invasion by Apicomplexan Parasites: The Junction Conundrum

  In addition to de novo actin polymerization at the junction, tachyzoite invasion also requires disorganization of the host cortical actin meshwork.\n Based on this, a gelsolation model for gliding motility and zoite internalization, in which the acto-myosin system of the parasite is required as a...

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Published inPLoS pathogens Vol. 10; no. 9; p. e1004273
Main Authors Bargieri, Daniel, Lagal, Vanessa, Andenmatten, Nicole, Tardieux, Isabelle, Meissner, Markus, Ménard, Robert
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.09.2014
Public Library of Science (PLoS)
Subjects
Animals
Apicomplexa - pathogenicity
Bacteriology
Biochemistry, Molecular Biology
Biology and Life Sciences
Cell Adhesion
Control
Cytoskeleton
Development and progression
Host-Parasite Interactions
Humans
Life Sciences
Malaria
Parasites
Pathogens
Physiological aspects
Plasmodium falciparum
Protozoan Infections - parasitology
Review
Sporozoa
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Summary:  In addition to de novo actin polymerization at the junction, tachyzoite invasion also requires disorganization of the host cortical actin meshwork.\n Based on this, a gelsolation model for gliding motility and zoite internalization, in which the acto-myosin system of the parasite is required as a clutch for force transmission but not for the generation of the force itself, has recently been proposed [32]. Whether the zoite provides all pieces of the junction, or whether the host cell also provides receptors, possibly located in specific microdomains, is also unclear. [...]it now appears that the force required for gliding motility and host cell entry might, at least in Toxoplasma, be generated in a motor-independent manner.
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004273