Gene Expression during the Life Cycle of Drosophila melanogaster

• Published in: Science (American Association for the Advancement of Science) Vol. 297; no. 5590; pp. 2270 - 2275
• Main Authors: Arbeitman, Michelle N., Eileen E. M. Furlong, Imam, Farhad, Johnson, Eric, Null, Brian H., Baker, Bruce S., Krasnow, Mark A., Scott, Matthew P., Davis, Ronald W., White, Kevin P.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 27.09.2002; The American Association for the Advancement of Science
• Subjects: Adult insects; Adults; Aging (Individuals); Algorithms; Animals; Biological and medical sciences; Cluster Analysis; Developmental biology; Developmental Stages; Drosophila; Drosophila melanogaster - embryology; Drosophila melanogaster - genetics; Drosophila melanogaster - growth & development; Drosophila Proteins - genetics; Drosophila Proteins - physiology; Embryo, Nonmammalian - physiology; Embryos; Female; Fundamental and applied biological sciences. Psychology; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes; Genes, Insect; Genomics; Germ cells; Germ Cells - physiology; Insect larvae; Larva - genetics; Larval development; Life Cycle Stages - genetics; Male; Mathematics; Molecular and cellular biology; Molecular biology; Molecular genetics; Mutation; Oligonucleotide Array Sequence Analysis; Organ Specificity; Pupa - genetics; Pupae; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sex Characteristics; Statistical Analysis; Transcription, Genetic; Transcription. Transcription factor. Splicing. Rna processing; Transcripts (Written Records); United States; Transcription; Insecta; Gene expression; Drosophilidae; Life cycle; Regulation(control); Gene; Arthropoda; Development; Invertebrata; Molecular biology; Genome; Drosophila melanogaster; Diptera
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1072152

Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.