A Rare Case of Ovarian Cancer Presenting with Paraneoplastic Cerebellar Degeneration and Limbic Encephalitis

• Published in: Chinese medical journal Vol. 128; no. 19; pp. 2685 - 2687
• Main Authors: Li, Wei-Hua, Cao, Dong-Yan, Shen, Keng, Yang, Jia-Xin
• Format: Journal Article
• Language: English
• Published: China Medknow Publications Pvt Ltd 05.10.2015; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Science,Beijing 100730,China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Adult; Anti-Yo Antibody; Ovarian Cancer; Paraneoplastic Cerebellar Degeneration; Paraneoplastic Limbic Encephalitis; Paraneoplastic Neurological Syndromes; Antigens; Ataxia; Brain diseases; Care and treatment; Case studies; Chemotherapy; Clinical Practice; Diagnosis; Disease; Encephalitis; Female; Gynecology; Hospitals; Humans; Immunoglobulins; Limbic Encephalitis - diagnosis; Limbic Encephalitis - etiology; Lymphatic system; Medical imaging; Medical prognosis; Metastasis; Nervous system; Neurodegeneration; NMR; Nuclear magnetic resonance; Obstetrics; Ovarian cancer; Ovarian Neoplasms - complications; Ovarian Neoplasms - diagnosis; Paraneoplastic Cerebellar Degeneration - diagnosis; Paraneoplastic Cerebellar Degeneration - etiology; Paraneoplastic syndromes; Patients; Vertigo; 卵巢癌; 变性; 合并; 小脑; 癌症患者; 神经系统疾病; 肿瘤; 脑炎; China; Ovarian Cancer; Anti-Yo Antibody; Paraneoplastic Limbic Encephalitis; Paraneoplastic Neurological Syndromes; Paraneoplastic Cerebellar Degeneration
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.166028

Paraneoplastic neurologic syndromes （PNSs） occur with increased frequency in patients with cancer and almost always antedate its diagnosis.These syndromes comprise a heterogeneous group of cancer-related neurologic diseases,and they may affect any part of the nervous system.The simultaneous involvement of different areas of the nervous system by the paraneoplastic process is not unusual.Until date,this is the first report of concurrent development of paraneoplastic cerebellar degeneration （PCD） and paraneoplastic limbic encephalitis （PLE） associated with the advanced ovarian cancer and anti-Yo antibodies following hepatitis B （HB） vaccination.The cause of most PNS is believed to be an immune response against neuronal proteins expressed by the tumor.