Multifunctional Skin-Like Electronics for Quantitative, Clinical Monitoring of Cutaneous Wound Healing

• Published in: Advanced healthcare materials Vol. 3; no. 10; pp. 1597 - 1607
• Main Authors: Hattori, Yoshiaki, Falgout, Leo, Lee, Woosik, Jung, Sung-Young, Poon, Emily, Lee, Jung Woo, Na, Ilyoun, Geisler, Amelia, Sadhwani, Divya, Zhang, Yihui, Su, Yewang, Wang, Xiaoqi, Liu, Zhuangjian, Xia, Jing, Cheng, Huanyu, Webb, R. Chad, Bonifas, Andrew P., Won, Philip, Jeong, Jae-Woong, Jang, Kyung-In, Song, Young Min, Nardone, Beatrice, Nodzenski, Michael, Fan, Jonathan A., Huang, Yonggang, West, Dennis P., Paller, Amy S., Alam, Murad, Yeo, Woon-Hong, Rogers, John A.
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.10.2014; Wiley-VCH; Wiley Subscription Services, Inc; Wiley
• Subjects: 60 APPLIED LIFE SCIENCES; Aged; Biological and medical sciences; clinical study; Electronic systems; Electronics; Electronics, Medical - instrumentation; epidermal electronics; Equipment Design; Female; Humans; Injuries; Laminates; Male; Management; Medical sciences; Middle Aged; Monitoring, Physiologic - instrumentation; multifunctional; Platforms; Reuse; Sensors; Silicones; Skin Temperature - physiology; skin-like; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical Tape; Technology. Biomaterials. Equipments; Thermography - instrumentation; Wound healing; Wound Healing - physiology; wound monitoring; Electronics; Skin; Surveillance; Cicatrization; Monitoring; Quantitative analysis; clinical study; epidermal electronics; multifunctional; skin-like; wound monitoring
• ISSN: 2192-2640; 2192-2659; 2192-2659
• DOI: 10.1002/adhm.201400073

Non‐invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time‐dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of “epidermal” electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management. A skin‐like, conformal electronics platform that can softly and reversibly laminate perilesionally at the sites of cutaneous wounds is presented to provide highly accurate, quantitative data of relevance to management of healing cascades in surgical site wounds. The use of this type of “epidermal electronics system” in a clinical setting with human subjects defines a set of procedures in sterilization, reuse, and quantitative measurement.