Adipokines in Semen: Physiopathology and Effects on Spermatozoas

Adipokines are secreted by adipose tissue and could be the link between obesity and infertility. Different studies investigated the involvement of adipokines in reproductive functions but only a few have looked into the male part. This review assesses adipokine functions on male reproductive paramet...

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Published inInternational journal of endocrinology Vol. 2018; no. 2018; pp. 1 - 11
Main Authors Dupont, Joëlle, Fellahi, Soraya, McAvoy, Chloe, Bastard, Jean-Philippe, Elfassy, Yaelle, Levy, Rachel
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
Hindawi Limited
Wiley
Subjects
Adipose tissue
Animal genetic engineering
Animals
Biological markers
Body mass index
Cytokines
Endocrinology
Fertility
Gastrointestinal surgery
Infertility
Leptin
Life Sciences
Morphology
Motility
Obesity
Physiological aspects
Plasma
Public health
Review
Sperm
Spermatogenesis
Weight control
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Summary:Adipokines are secreted by adipose tissue and could be the link between obesity and infertility. Different studies investigated the involvement of adipokines in reproductive functions but only a few have looked into the male part. This review assesses adipokine functions on male reproductive parameters. Adiponectin seems to have a positive effect on sperm parameters, whereas other adipokines such as resistin or chemerin would have a rather deleterious effect on spermatogenesis. Semen parameters seem to be impacted when resistin and chemerin are increased: indeed, there is a decrease of sperm motility. Sperm morphology is improved when adiponectin is increased. The most studied adipokine, leptin, has a dual effect with a positive effect on sperm at physiological levels and a negative one for high seminal concentrations. Many semen parameters and fertility itself are disturbed according to semen adipokine levels, even if it is not the only interfering element. Taken together, adipokines are found in human and animal semen and most of them or their receptors are expressed in male genital tract. Although the pathophysiological role of adipokines in semen is not clearly elucidated, the adipokines could influence sperm functionality and could be potential biomarkers of male fertility.
Bibliography:ObjectType-Article-2
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Academic Editor: Rosaria Meccariello
ISSN:1687-8337
1687-8345
DOI:10.1155/2018/3906490