Recent advances in research on Crimean-Congo hemorrhagic fever

• Published in: Journal of clinical virology Vol. 64; pp. 137 - 143
• Main Authors: Papa, Anna, Mirazimi, Ali, Köksal, Iftihar, Estrada-Pena, Augustin, Feldmann, Heinz
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2015
• Subjects: Allergy and Immunology; Animals; Antiviral Agents - therapeutic use; Communicable Diseases, Emerging; Crimean-Congo hemorrhagic fever; Ecology; Epidemiology; Hemorrhagic Fever Virus, Crimean-Congo - immunology; Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity; Hemorrhagic Fever, Crimean - diagnosis; Hemorrhagic Fever, Crimean - epidemiology; Hemorrhagic Fever, Crimean - prevention & control; Hemorrhagic Fever, Crimean - therapy; Humans; Infectious Disease; Medicin och hälsovetenskap; Ticks - virology; Viral Vaccines; Zoonoses; Epidemiology; Ecology; Crimean-Congo hemorrhagic fever
• ISSN: 1386-6532; 1873-5967; 1873-5967
• DOI: 10.1016/j.jcv.2014.08.029

Abstract Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities.