Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery

• Published in: PloS one Vol. 12; no. 6; p. e0177170
• Main Authors: Maimaituxun, Gulinu, Shimabukuro, Michio, Salim, Hotimah Masdan, Tabata, Minoru, Yuji, Daisuke, Morimoto, Yoshihisa, Akasaka, Takeshi, Matsuura, Tomomi, Yagi, Shusuke, Fukuda, Daiju, Yamada, Hirotsugu, Soeki, Takeshi, Sugimoto, Takaki, Tanaka, Masashi, Takanashi, Shuichiro, Sata, Masataka
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.06.2017; Public Library of Science (PLoS)
• Subjects: Abdomen; Adiponectin; Adipose tissue; Adipose Tissue - pathology; Aged; Analysis; Arteriosclerosis; Atherosclerosis; Biology and Life Sciences; Body fat; Body mass; Body mass index; Bypasses; C-reactive protein; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Coronary artery; Coronary Artery Bypass; Coronary vessels; Determinants; Diabetes; Diabetes mellitus; Diagnostic systems; Dyslipidemia; Female; Gender; Gene expression; Grafting; Health risk assessment; Heart; Heart surgery; Heart Valves - surgery; Hospitals; Humans; Hypertension; Iodine; Low density lipoprotein; Male; Markers; Medical imaging; Medicine; Medicine and Health Sciences; Men; Metabolism; Multivariate Analysis; Obesity; Organ Size; Patients; Pericardium - pathology; Proteins; Regression Analysis; Risk analysis; Risk factors; Sensors; Sex Characteristics; Surface area; Surgery; University graduates; Womens health; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0177170

Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown. Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG). In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005). Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms.