Age and sex differences in reward behavior in adolescent and adult rats

• Published in: Developmental psychobiology Vol. 56; no. 4; pp. 611 - 621
• Main Authors: Hammerslag, Lindsey R., Gulley, Joshua M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2014
• Subjects: adolescent; Age Factors; Animals; Behavior, Animal - physiology; Conditioning, Classical - physiology; extinction; Extinction, Psychological - physiology; Female; learning; Male; Pavlovian approach; rat; Rats; Rats, Sprague-Dawley; reacquisition; Reward; reward devaluation; reward processing; sex; Sex Characteristics; extinction; reward processing; rat; Pavlovian approach; sex; adolescent; learning; reward devaluation; reacquisition
• ISSN: 0012-1630; 1098-2302
• DOI: 10.1002/dev.21127

ABSTRACT Compared to adults, adolescents are at heightened risk for drug abuse and dependence. One of the factors contributing to this vulnerability may be age‐dependent differences in reward processing, with adolescents approaching reward through stimulus‐directed, rather than goal‐directed, processes. However, the empirical evidence for this in rodent models of adolescence, particularly those that investigate both sexes, is limited. To address this, male and female rats that were adolescents (P30) or adults (P98) at the start of the experiment were trained in a Pavlovian approach (PA) task and were subsequently tested for the effects of reward devaluation, extinction, and re‐acquisition. We found significant interactions between age and sex: females had enhanced acquisition of PA and poorer extinction, relative to males, while adolescents and females were less sensitive to reward devaluation than male adults. These results suggest that females and adolescents exhibit reward behavior that is more stimulus‐directed, rather than goal‐directed. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 611–621, 2014.