Obsessive-Compulsive Schizophrenia: Clinical andConceptual Perspective

• Published in: Psychiatric annals Vol. 48; no. 12; pp. 552 - 556
• Main Authors: Hwang, Michael, Sood, Ashvin, Riaz, Burhan, Poyurovsky, Michael
• Format: Journal Article
• Language: English
• Published: Thorofare SLACK INCORPORATED 01.12.2018
• Subjects: Antipsychotics; Comorbidity; Dopamine; Mental disorders; Mental health; Neurobiology; Neuroses; Obsessive compulsive disorder; Psychiatry; Psychopathology; Psychosis; Psychotropic drugs; Schizophrenia; Substance abuse treatment
• ISSN: 0048-5713; 1938-2456
• DOI: 10.3928/00485713-20181108-02

Schizophrenia has long challenged clinicians and researchers due to its diverse clinical phenomena and high rate of comorbidity. Emerging evidence supports a specific neurobiological basis of behavioral phenotype and promotes a conceptual shift toward a symptom dimensional approach. This led to modifications in the Diagnostic and Statistical Manual of Mental Disorders , fifth edition, and introduction of the National Institute of Mental Health initiative, Research Diagnostic Criteria, which provides greater latitude for recognition and exploration of coexisting psychiatric conditions. The obessive compulsive (OC) schizophrenia may offer a unique avenue to explore the interface between neurobiological and psychosocial pathogenesis of specific symptom dimensions in schizophrenic spectrum disorder. Current available evidence suggests that obsessive-compulsive symptoms (OCS) in schizophrenia possess multiple biopsychosocial pathogenesis that require individualized specific treatment intervention for optimal outcome. In addition, introduction of atypical antipsychotics has been reported to induce de novo or exacerbate preexisting OCS. Further efforts to understand the biopsychosocial pathogenesis of OC phenomena in schizophrenia are needed to advance meaningful approaches in clinical and research strategy. [ Psychiatr Ann . 2018;48(12):552–556.]