Somatostatin Analogs Treated Small Intestinal Neuroendocrine Tumor Patients Circulating MicroRNAs

• Published in: PloS one Vol. 10; no. 5; p. e0125553
• Main Authors: Li, Su-Chen, Khan, Mohid, Caplin, Martyn, Meyer, Tim, Öberg, Kjell, Giandomenico, Valeria
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.05.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Analogs; Analysis; Biomarkers; Biomarkers, Tumor; Cancer; Care and treatment; Development and progression; Female; Gastroenterology; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic aspects; Hospitals; Humans; Intestinal Neoplasms - blood; Intestinal Neoplasms - drug therapy; Intestinal Neoplasms - genetics; Intestinal Neoplasms - pathology; Intestine; Laboratories; Liver; Male; Metabolism; Metastases; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miRNA; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Neuroendocrine tumors; Neuroendocrine Tumors - blood; Neuroendocrine Tumors - drug therapy; Neuroendocrine Tumors - genetics; Neuroendocrine Tumors - pathology; Oncology; Patient outcomes; Patients; Real-Time Polymerase Chain Reaction; Ribonucleic acid; Risk factors; RNA; Science; Somatostatin; Somatostatin - analogs & derivatives; Somatostatin - therapeutic use; Stem cells; Tissues; Tumors; United States

We previously detected and investigated nine altered microRNAs in small intestinal neuroendocrine tumor (SI-NET) tissues at different stages of disease. The aims of this study are to: 1) analyze whether SI-NET tissue microRNAs can be also detected in patient serum samples, 2) investigate a potential...