Synthesis of [3′‐ 14 C] coenzyme Q 10

Abstract Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐ 14 C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. Th...

Full description

Saved in:
Bibliographic Details
Published inJournal of labelled compounds & radiopharmaceuticals Vol. 45; no. 10; pp. 823 - 829
Main Authors Hamamura, Kimio, Yamatsu, Isao, Minami, Norio, Yamagishi, Yoji, Inai, Yuichi, Kijima, Shizumasa, Nakamura, Tetsuya
Format Journal Article
LanguageEnglish
Published 01.09.2002
Online AccessGet full text

Cover

Abstract Abstract Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐ 14 C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. The specific radioactivity and radiochemical purity are sufficiently high to enable us to use this labelled form of coenzyme Q 10 in metabolic studies. Copyright © 2002 John Wiley & Sons, Ltd.
AbstractList Abstract Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐ 14 C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. The specific radioactivity and radiochemical purity are sufficiently high to enable us to use this labelled form of coenzyme Q 10 in metabolic studies. Copyright © 2002 John Wiley & Sons, Ltd.
Author Minami, Norio
Inai, Yuichi
Kijima, Shizumasa
Yamatsu, Isao
Nakamura, Tetsuya
Hamamura, Kimio
Yamagishi, Yoji
Author_xml – sequence: 1
  givenname: Kimio
  surname: Hamamura
  fullname: Hamamura, Kimio
– sequence: 2
  givenname: Isao
  surname: Yamatsu
  fullname: Yamatsu, Isao
– sequence: 3
  givenname: Norio
  surname: Minami
  fullname: Minami, Norio
– sequence: 4
  givenname: Yoji
  surname: Yamagishi
  fullname: Yamagishi, Yoji
– sequence: 5
  givenname: Yuichi
  surname: Inai
  fullname: Inai, Yuichi
– sequence: 6
  givenname: Shizumasa
  surname: Kijima
  fullname: Kijima, Shizumasa
– sequence: 7
  givenname: Tetsuya
  surname: Nakamura
  fullname: Nakamura, Tetsuya
BookMark eNotj81KAzEUhYNUcFoFHyFLXaTem8TMnaUM_kFBxO5Ewkx-sKWdkcTNuOoj-Cw-Up_EKbo6iwPnO9-UTbq-C4ydI8wRQF6tNy7Nr4mOWIFQVQKV1hNWgDJSaAJ1wqY5rwHGTuuCXb4M3ed7yKvM-8hf1X73s999c9S8fuOuD93XsA38mSOcsuPYbHI4-88ZW97dLusHsXi6f6xvFsKVkkTwhhwGpchQ5bWPSkd00BojTazANFqP4LaV4NCPJ6KP0JKisgwksXFqxi7-Zl3qc04h2o-02jZpsAj2YGgPhnY0VL_qfUR9
CitedBy_id crossref_primary_10_1016_j_supflu_2020_105046
crossref_primary_10_1039_B211521M
crossref_primary_10_1002_jlcr_587
crossref_primary_10_1002_rcm_6529
crossref_primary_10_1016_j_biortech_2010_05_020
crossref_primary_10_1016_j_biortech_2009_09_009
crossref_primary_10_1002_jlcr_3083
crossref_primary_10_1016_j_supflu_2007_10_011
crossref_primary_10_1186_s40643_023_00726_4
crossref_primary_10_1365_s10337_010_1507_z
crossref_primary_10_1016_j_phytochem_2011_03_015
crossref_primary_10_1007_s00044_009_9226_4
crossref_primary_10_1016_j_jpba_2007_10_014
crossref_primary_10_1016_j_fluid_2009_04_008
crossref_primary_10_1021_jo101043m
crossref_primary_10_1002_hlca_200890211
crossref_primary_10_1080_10426500701795043
crossref_primary_10_3389_fpls_2016_01263
Cites_doi 10.1016/0304-4165(83)90325-2
10.1248/bpb1978.12.640
10.1074/jbc.272.31.19199
10.1016/0304-4165(84)90167-3
10.1002/biof.5520090205
10.1016/0040-4039(80)80026-8
10.1016/S0021-9258(19)49428-3
10.3177/jnsv.31.147
10.1021/cr60287a005
10.1002/jlcr.587
10.3177/jnsv.31.115
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.1002/jlcr.588
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1099-1344
EndPage 829
ExternalDocumentID 10_1002_jlcr_588
GroupedDBID ---
.3N
.GA
.GJ
.Y3
05W
0R~
10A
1L6
1OB
1OC
1ZS
31~
33P
3SF
3WU
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5GY
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A03
AAESR
AAEVG
AAHHS
AANLZ
AAONW
AASGY
AAXRX
AAYXX
AAZKR
ABCQN
ABCUV
ABDBF
ABEML
ABIJN
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFS
ACIWK
ACNCT
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
AEEZP
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFPM
AFGKR
AFPWT
AFZJQ
AHBTC
AI.
AITYG
AIURR
AIWBW
AJBDE
AJXKR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ATUGU
AUFTA
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMNLL
BMXJE
BNHUX
BROTX
BRXPI
BY8
CITATION
CS3
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRSTM
DU5
EBD
EBS
EJD
F00
F01
F04
F5P
FEDTE
G-S
G.N
GNP
GODZA
GWYGA
H.T
H.X
HBH
HF~
HGLYW
HHY
HHZ
HVGLF
HZ~
IX1
J0M
JPC
KQQ
LATKE
LAW
LC2
LC3
LEEKS
LITHE
LOXES
LP6
LP7
LUTES
LYRES
M6Q
MEWTI
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
N04
N05
N9A
NF~
NNB
O66
O9-
OIG
P2P
P2W
P2X
P4D
PALCI
Q.N
Q11
QB0
QRW
R.K
RIWAO
ROL
RWI
RX1
SAMSI
SUPJJ
TUS
UB1
V2E
VH1
W8V
W99
WBFHL
WBKPD
WH7
WIB
WIH
WIK
WJL
WOHZO
WQJ
WRC
WUP
WWP
WXSBR
WYISQ
XG1
XV2
YCJ
ZZTAW
~IA
~WT
ID FETCH-LOGICAL-c728-ed68c1e338689d4df34f1c0b6626f906a44994bb20c1d009fdf0b83877e821ac3
ISSN 0362-4803
IngestDate Fri Aug 23 02:40:58 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c728-ed68c1e338689d4df34f1c0b6626f906a44994bb20c1d009fdf0b83877e821ac3
PageCount 7
ParticipantIDs crossref_primary_10_1002_jlcr_588
PublicationCentury 2000
PublicationDate 2002-09-00
PublicationDateYYYYMMDD 2002-09-01
PublicationDate_xml – month: 09
  year: 2002
  text: 2002-09-00
PublicationDecade 2000
PublicationTitle Journal of labelled compounds & radiopharmaceuticals
PublicationYear 2002
References Nakamura T (e_1_2_1_5_2) 1980
Research Committee of Fat Soluble Vitamins (e_1_2_1_17_2) 1988; 62
Nakamura T (e_1_2_1_10_2) 1986; 28
e_1_2_1_6_2
e_1_2_1_7_2
Ramasarma T (e_1_2_1_3_2) 1985
Fujita T (e_1_2_1_13_2) 1972; 6
e_1_2_1_2_2
e_1_2_1_11_2
e_1_2_1_12_2
Teclebrhan H (e_1_2_1_4_2) 1993; 268
e_1_2_1_15_2
e_1_2_1_16_2
e_1_2_1_14_2
e_1_2_1_8_2
e_1_2_1_9_2
References_xml – ident: e_1_2_1_6_2
  doi: 10.1016/0304-4165(83)90325-2
– ident: e_1_2_1_12_2
  doi: 10.1248/bpb1978.12.640
– volume: 28
  start-page: 730
  year: 1986
  ident: e_1_2_1_10_2
  publication-title: Acta Paediatr Jpn
  contributor:
    fullname: Nakamura T
– ident: e_1_2_1_2_2
  doi: 10.1074/jbc.272.31.19199
– start-page: 3
  volume-title: Biomedical and Clinical Aspects of Coenzyme Q10
  year: 1980
  ident: e_1_2_1_5_2
  contributor:
    fullname: Nakamura T
– start-page: 67
  volume-title: Coenzyme Q
  year: 1985
  ident: e_1_2_1_3_2
  contributor:
    fullname: Ramasarma T
– ident: e_1_2_1_7_2
  doi: 10.1016/0304-4165(84)90167-3
– ident: e_1_2_1_11_2
  doi: 10.1002/biof.5520090205
– ident: e_1_2_1_15_2
  doi: 10.1016/0040-4039(80)80026-8
– volume: 62
  start-page: 505
  year: 1988
  ident: e_1_2_1_17_2
  publication-title: Vitamins (Japan)
  contributor:
    fullname: Research Committee of Fat Soluble Vitamins
– volume: 268
  start-page: 23081
  year: 1993
  ident: e_1_2_1_4_2
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)49428-3
  contributor:
    fullname: Teclebrhan H
– ident: e_1_2_1_9_2
  doi: 10.3177/jnsv.31.147
– ident: e_1_2_1_14_2
  doi: 10.1021/cr60287a005
– ident: e_1_2_1_16_2
  doi: 10.1002/jlcr.587
– volume: 6
  start-page: 707
  year: 1972
  ident: e_1_2_1_13_2
  publication-title: Oyo Yakuri‐Pharmacometrics
  contributor:
    fullname: Fujita T
– ident: e_1_2_1_8_2
  doi: 10.3177/jnsv.31.115
SSID ssj0009944
Score 1.6012231
Snippet Abstract Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C]...
SourceID crossref
SourceType Aggregation Database
StartPage 823
Title Synthesis of [3′‐ 14 C] coenzyme Q 10
Volume 45
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NTtwwELa2cGgvqKWtSinISOVQrUL9l8Q5wlKEkKgEbCWkqlrFiQNZNdnV_hyW0z5Cn6WPtE_COE6yWeBAe4gVOY4je0bjmcnMNwh99oU5JKVwtKbSEaADOMp3XcdTnNMQrtg3Cc7n373TH-Ls2r1utWaNqKXpRB1Ed0_mlfwPVaEP6GqyZP-BsvWk0AH3QF9ogcLQPovGV7Mc9LcSUmTfPeJl6MIRq2MY2lS0O_vusQEBye9mmW5ftMsIz8cqKXCE8eMXiW5DU29pXHDGKIzTwfC26fweLyVXFmbTkU0sSzMb1VWIEXgwGU8LGTQO6-7zNA-ztPxjtDr6xrjDiiNh0E9XvBGsDrdaycKSxAotbYWqQQGl3OI8VlLXgkhW3EUaMlQy3jyOrUPkkaS3yLH939HowLWFAVfBtB8ccnXooYVpZj3zZg_efIHWmR-4xm4_vlwijwWBWCKPwXIq3GLCvlbfbGgyDZWk-xptlITDh5Yx3qCWzjfRy05Vwu8t-lIzCB4k-CdfzP8u5n8wFbjzC1cMgS8wJe9Q9-Rbt3PqlLUxnMhn0tGxJyOqOZeeDGIRJ1wkNCLKA_s0CYgXCrBkhVKMRDSG1SRxQpTk0ve1ZDSM-Hu0lg9y_QHhMBFcu9wUKoiFAutTUw-MYA2Tw-w-2UJ71TJ7Q4uA0nu4iR-fMWYbvVoyzCe0NhlN9Q4odBO1W2z9PYxzRr8
link.rule.ids 315,786,790,27957,27958
linkProvider Wiley-Blackwell
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+of+%5B3%E2%80%B2%E2%80%90+14+C%5D+coenzyme+Q+10&rft.jtitle=Journal+of+labelled+compounds+%26+radiopharmaceuticals&rft.au=Hamamura%2C+Kimio&rft.au=Yamatsu%2C+Isao&rft.au=Minami%2C+Norio&rft.au=Yamagishi%2C+Yoji&rft.date=2002-09-01&rft.issn=0362-4803&rft.eissn=1099-1344&rft.volume=45&rft.issue=10&rft.spage=823&rft.epage=829&rft_id=info:doi/10.1002%2Fjlcr.588&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_jlcr_588
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0362-4803&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0362-4803&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0362-4803&client=summon