Synthesis of [3′‐ 14 C] coenzyme Q 10

Abstract Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐ 14 C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. Th...

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Published inJournal of labelled compounds & radiopharmaceuticals Vol. 45; no. 10; pp. 823 - 829
Main Authors Hamamura, Kimio, Yamatsu, Isao, Minami, Norio, Yamagishi, Yoji, Inai, Yuichi, Kijima, Shizumasa, Nakamura, Tetsuya
Format Journal Article
LanguageEnglish
Published 01.09.2002
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Summary:Abstract Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐ 14 C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. The specific radioactivity and radiochemical purity are sufficiently high to enable us to use this labelled form of coenzyme Q 10 in metabolic studies. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.588