Cyclic diguanylate riboswitches control bacterial pathogenesis mechanisms

• Published in: PLoS pathogens Vol. 15; no. 2; p. e1007529
• Main Author: Tamayo, Rita
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.02.2019; Public Library of Science (PLoS)
• Subjects: Adhesins, Bacterial - genetics; Adhesins, Bacterial - metabolism; Bacteria; Bacteria - pathogenicity; Bacterial infections; Bacterial Infections - metabolism; Bacterial Proteins; Bacteriology; Binding sites; Biocompatibility; Biology and Life Sciences; Biosensors; Cellular signal transduction; Clostridium difficile; Cyclic GMP - analogs & derivatives; Cyclic GMP - metabolism; Cytotoxicity; Development and progression; Enzymes; Gene expression; Gene Expression Regulation, Bacterial - physiology; Genetic aspects; Genomes; Infections; Ligands; Medicine and Health Sciences; Motility; Nucleotides; Pathogenesis; Pearls; Phenotypes; Physiological aspects; Proteins; Riboswitch - physiology; Riboswitches; Toxicity; Toxins; Transcription termination; Waterborne diseases
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1007529

The gram-negative Vibrio cholerae encodes two class I c-di-GMP riboswitches that respond to the ligand in opposing directions, and neither function by controlling transcription termination [21, 22]. [...]regulatory attributes cannot necessarily be extrapolated to c-di-GMP riboswitches in other bacterial species but must be evaluated in each context. How does c-di-GMP signaling through riboswitches impact pathogenesis? Because its genome contains a large number of c-di-GMP riboswitches regulating genes with measurable phenotypes, C. difficile serves as an excellent model for understanding how c-di-GMP riboswitches function in vivo. [...]c-di-GMP indirectly inhibits expression of tcdR, tcdA, and tcdB, resulting in reduced toxin production and cytotoxicity [5]. [...]a number of other pathogenic bacteria encode putative c-di-GMP riboswitches [18, 19].