Direct cell-to-cell transmission of respiratory viruses: The fast lanes

• Published in: PLoS pathogens Vol. 14; no. 6; p. e1007015
• Main Authors: Cifuentes-Muñoz, Nicolás, Dutch, Rebecca Ellis, Cattaneo, Roberto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.06.2018; Public Library of Science (PLoS)
• Subjects: Analysis; Biochemistry; Biology and life sciences; Genomes; Genomics; Health aspects; Humans; Immunoglobulins; Infection; Infections; Influenza; Infrastructure; Measles; Medicine and Health Sciences; Pathogens; Paths; Pearls; Proteins; Respiratory syncytial virus; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - transmission; Respiratory Tract Infections - virology; Virology; Viruses; Viruses - classification; Viruses - isolation & purification; Viruses - pathogenicity; United States > US; Kentucky
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1007015

Other fast lanes, while forming below the cell surface, push released particles to “surf” towards noninfected cells [7]. [...]some viruses take advantage of structures built by circulating cells to communicate, such as the immunological synapse, to spread more rapidly [2]. [...]the lowest portion of the tract that lacks cilia and mucus is safeguarded by macrophages that destroy particles. [...]mechanisms that allow viral spread within the airway epithelia without particle release would be highly advantageous, and recent studies suggest that some respiratory viruses have indeed developed alternative means of spread. [...]the complete assembly of virions is not needed, and direct cell-to-cell transfer of viral genetic material, proteins, nucleocapsids, or replication bodies is most likely occurring. [...]disruption of intercellular extensions or intercellular pores by different means leads to reduced and/or less efficient viral spread.