Hyperpolarized 129 Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging

In the present study, a balanced steady‐state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized 129 Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting ima...

Full description

Saved in:
Bibliographic Details
Published inNMR in biomedicine Vol. 24; no. 10; pp. 1343 - 1352
Main Authors Imai, Hirohiko, Kimura, Atsuomi, Hori, Yuki, Iguchi, Satoshi, Kitao, Takuya, Okubo, Emi, Ito, Tsuyoshi, Matsuzaki, Toshio, Fujiwara, Hideaki
Format Journal Article
LanguageEnglish
Published 01.12.2011
Online AccessGet full text

Cover

More Information
Summary:In the present study, a balanced steady‐state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized 129 Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, 129 Xe lung images in end‐inspiratory and end‐expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase‐induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase‐treated mice. Copyright © 2011 John Wiley & Sons, Ltd.
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.1697