Emerging function of fat mass and obesity-associated protein (fto)

[...]germline loss of Fto causes perinatal lethality and growth retardation, which may give rise to secondary effects that are unrelated to the mechanism by which variation in FTO affects human metabolism [7], [8]. [...]the observation that RER is decreased in the germline and adult onset Fto ko mic...

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Published inPLoS genetics Vol. 9; no. 1; p. e1003223
Main Authors Müller, Timo D, Tschöp, Matthias H, Hofmann, Susanna
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.01.2013
Public Library of Science (PLoS)
Subjects
Adipose tissues
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Animals
Biology
Body Mass Index
Cardiovascular disease
Central Nervous System - metabolism
Diabetes
Diet
Disease Models, Animal
Food
Genetic aspects
Genome-Wide Association Study
Genomics
Genotype & phenotype
Health aspects
Homeostasis
Humans
Medicine
Mice
Obesity
Obesity - genetics
Physiological aspects
Proteins
Proteins - genetics
Quantitative genetics
Risk factors
Rodents
Studies
Weight control
Germany
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Summary:[...]germline loss of Fto causes perinatal lethality and growth retardation, which may give rise to secondary effects that are unrelated to the mechanism by which variation in FTO affects human metabolism [7], [8]. [...]the observation that RER is decreased in the germline and adult onset Fto ko mice points to a role of Fto in regulating peripheral metabolism and substrate utilization.
Bibliography:ObjectType-Article-1
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The authors have declared that no competing interests exist.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1003223