Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigs

To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus. At 24–48 hours postinoculation, the pigs exhibited severe diarrhea and vomiting, fecal shedding, viremia, and severe atrophic enteritis. The...

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Published inEmerging infectious diseases Vol. 20; no. 4; pp. 662 - 671
Main Authors Jung, Kwonil, Wang, Qiuhong, Scheuer, Kelly A, Lu, Zhongyan, Zhang, Yan, Saif, Linda J
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.04.2014
Centers for Disease Control and Prevention
Subjects
Animals
Coronavirus Infections - pathology
Coronavirus Infections - virology
Development and progression
Diarrhea
Diarrhea - virology
Dispatch
Epidemics
Feces - virology
Germ-Free Life
Infection
Ohio
porcine epidemic diarrhea virus
Porcine epidemic diarrhea virus - isolation & purification
porcine epidemic diarrhea, pathogenesis, outbreak, USA, gnotobiotic pigs, US strain, pigs, strain PC21A, viruses, enteropathogenic
Resveratrol
Swine
Swine Diseases - pathology
Swine Diseases - virology
Viremia - virology
Virulence - genetics
Virus Shedding
Ohio
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Summary:To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus. At 24–48 hours postinoculation, the pigs exhibited severe diarrhea and vomiting, fecal shedding, viremia, and severe atrophic enteritis. These findings confirm that strain PC21A is highly enteropathogenic.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1080-6040
1080-6059
DOI:10.3201/eid2004.131685