Putting the brakes on centromere drive in Mimulus

• Published in: PLoS genetics Vol. 17; no. 4; p. e1009494
• Main Authors: Chang, Ching-Ho, Malik, Harmit S
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.04.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Centromere - genetics; Centromere protein A; Centromeres; Chromosomes; Chromosomes, Plant; Costs; Fertility; Gene loci; Genomes; Insects; Meiosis; Mimulus - genetics; Mutation; Physiological aspects; Population genetics; Proteins; Research and Analysis Methods; Satellite DNA; Satellites; Sibling species; United States
• ISSN: 1553-7404; 1553-7390; 1553-7404
• DOI: 10.1371/journal.pgen.1009494

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. [...]suppressors of centromere drive are predicted to arise, especially in centromeric proteins like CenH3/CENP-A. In the first stage (“Centromere drive”), a chromosome with non-driving centromeres (D−) acquires structural mutations, such as an inversion, and expansion of a centromeric satellite, which confers a transmission advantage in asymmetric female meiosis. Eventually, as suppressor alleles fix in populations, they negate the meiotic advantage of D chromosomes, which will then be lost and replaced by D− chromosomes in the third stage of the process (“Loss of drive”), resulting in fixed changes in CenH3A and potentially centromeric satellites. https://doi.org/10.1371/journal.pgen.1009494.g001 M. guttatus D drives strongly against its counterpart centromere (d) from the self-fertilizing sister species Mimulus nasutus (D:d = >98:2 [7]), and it drives weakly against intraspecies D− (D: