Autochthonous Transmission of East/Central/South African Genotype Chikungunya Virus, Brazil

• Published in: Emerging infectious diseases Vol. 23; no. 10; pp. 1737 - 1739
• Main Authors: Cunha, Marcela S, Cruz, Nádia V G, Schnellrath, Laila C, Medaglia, Maria Luiza Gomes, Casotto, Michele E, Albano, Rodolpho M, Costa, Luciana J, Damaso, Clarissa R
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.10.2017; Centers for Disease Control and Prevention
• Subjects: Adolescent; Adult; Aedes - virology; Africa - epidemiology; Analysis; Animals; arboviruses; Autochthonous Transmission of East/Central/South African Genotype Chikungunya Virus, Brazil; Brazil - epidemiology; Cercopithecus aethiops; Chikungunya Fever - epidemiology; Chikungunya Fever - transmission; Chikungunya Fever - virology; Chikungunya virus; Chikungunya virus - classification; Chikungunya virus - genetics; Chikungunya virus - isolation & purification; dengue virus; ECSA genotype; Female; Genetic aspects; Genomes; Genomics; Genotype; Humans; Insect Vectors - virology; Male; Mosquitoes; Phylogeny; Proteins; Research Letter; RNA, Viral - genetics; vector-borne infections; Vero Cells; Zika virus; Brazil; mosquitoes; viruses; ECSA genotype; vector-borne infections; Chikungunya virus; arboviruses; dengue virus; Brazil; alphaviruses; Zika virus; East/Central/South African Genotype
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2310.161855

We isolated East/Central/South African genotype chikungunya virus during the 2016 epidemic in Rio de Janeiro, Brazil. Genome sequencing revealed unique mutations in the nonstructural protein 4 (NSP4-A481D) and envelope protein 1 (E1-K211T). Moreover, all Brazil East/Central/South isolates shared the exclusive mutations E1-M407L and E2-A103T.