Carbapenemase-Producing Enterobacteriaceae and Nonfermentative Bacteria, the Philippines, 2013-2016

• Published in: Emerging infectious diseases Vol. 23; no. 9; pp. 1597 - 1598
• Main Authors: Velasco, John Mark, Valderama, Maria Theresa, Peacock, Trent, Warawadee, Nirdnoy, Nogrado, Kathyleen, Navarro, Fatima Claire, Chua, Jr, Domingo, Apichai, Srijan, Sirigade, Ruekit, Macareo, Louis R, Swierczewski, Brett
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.09.2017; Centers for Disease Control and Prevention
• Subjects: and Nonfermentative Bacteria, the Philippines, 2013–2016; Anti-Bacterial Agents - pharmacology; antimicrobial resistance; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Beta lactamases; beta-Lactam Resistance - genetics; beta-Lactamases - genetics; beta-Lactamases - metabolism; Carbapenem-Resistant Enterobacteriaceae - drug effects; Carbapenem-Resistant Enterobacteriaceae - genetics; Carbapenem-Resistant Enterobacteriaceae - isolation & purification; Carbapenemase-Producing; Carbapenems - pharmacology; enteric infections; Enterobacteriaceae Infections - drug therapy; Enterobacteriaceae Infections - epidemiology; Enterobacteriaceae Infections - microbiology; Gene Expression; Health aspects; Humans; Isoenzymes - genetics; Isoenzymes - metabolism; Microbial drug resistance; Microbial Sensitivity Tests; multidrug resistance; Multilocus Sequence Typing; New Delhi metallo-β-lactamase–producing; Philippines - epidemiology; Plasmids - chemistry; Plasmids - metabolism; Pneumonia; Prevalence; Research Letter; Tertiary Care Centers; Philippines; India; military treatment facility; multidrug resistance; the Philippines; bacteria; antimicrobial resistance; carbapenemase-producing; nonfermentative bacteria; carbapenem-resistant; enteric infections; Enterobacteriaceae; New Delhi metallo-β-lactamase–producing
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2309.161237

During 2013-2016, we isolated bla - and bla -harboring Enterobacteriaceae and nonfermentative bacteria from patients in the Philippines. Of 130 carbapenem-resistant isolates tested, 45 were Carba NP-positive; 43 harbored bla , and 2 harbored bla . Multidrug-resistant microbial pathogen surveillance and antimicrobial drug stewardship are needed to prevent further spread of New Delhi metallo-β-lactamase variants.