Associations among depressive symptoms, childhood abuse, neuroticism, and adult stressful life events in the general adult population

• Published in: Neuropsychiatric disease and treatment Vol. 13; pp. 477 - 482
• Main Authors: Ono, Kotaro, Takaesu, Yoshikazu, Nakai, Yukiei, Shimura, Akiyoshi, Ono, Yasuyuki, Murakoshi, Akiko, Matsumoto, Yasunori, Tanabe, Hajime, Kusumi, Ichiro, Inoue, Takeshi
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Analysis; Child abuse; Child abuse & neglect; Childhood abuse; Childhood mental disorders; Depression; Depression (Mood disorder); Hypotheses; Mental depression; Mental disorders; Neuroticism; Original Research; Personality; Population; Prognosis; Psychiatry; Psychological aspects; Risk factors; Sex crimes; Stressful life events; Structural equation modeling; Structural equation modeling (SEM); Studies; Japan; United States > US; childhood abuse; depression; structural equation modeling; stressful life events; neuroticism
• ISSN: 1176-6328; 1178-2021; 1178-2021
• DOI: 10.2147/ndt.s128557

Recent studies have suggested that the interactions among several factors affect the onset, progression, and prognosis of major depressive disorder. This study investigated how childhood abuse, neuroticism, and adult stressful life events interact with one another and affect depressive symptoms in the general adult population. A total of 413 participants from the nonclinical general adult population completed the Patient Health Questionnaire-9, the Child Abuse and Trauma Scale, the neuroticism subscale of the shortened Eysenck Personality Questionnaire - Revised, and the Life Experiences Survey, which are self-report scales. Structural equation modeling (Mplus version 7.3) and single and multiple regressions were used to analyze the data. Childhood abuse, neuroticism, and negative evaluation of life events increased the severity of the depressive symptoms directly. Childhood abuse also indirectly increased the negative appraisal of life events and the severity of the depressive symptoms through enhanced neuroticism in the structural equation modeling. There was recall bias in this study. The causal relationship was not clear because this study was conducted using a cross-sectional design. This study suggested that neuroticism is the mediating factor for the two effects of childhood abuse on adulthood depressive symptoms and negative evaluation of life events. Childhood abuse directly and indirectly predicted the severity of depressive symptoms.