Remote Ischemic Preconditioning for the Prevention of Contrast-Induced Acute Kidney Injury in Diabetics Receiving Elective Percutaneous Coronary Intervention

• Published in: PloS one Vol. 11; no. 10; p. e0164256
• Main Authors: Balbir Singh, Gillian, Ann, Soe Hee, Park, Jongha, Chung, Hyun Chul, Lee, Jong Soo, Kim, Eun-Sook, Choi, Jung Il, Lee, Jiho, Kim, Shin-Jae, Shin, Eun-Seok
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.10.2016; Public Library of Science (PLoS)
• Subjects: Acute Kidney Injury - etiology; Acute Kidney Injury - prevention & control; Aged; Albumin; Angioplasty; Balloon angioplasty; Biology and Life Sciences; Blood flow; C-Reactive Protein - analysis; Calcium-binding protein; Cardiology; Chronic kidney failure; Contrast agents; Contrast Media - adverse effects; Coronary Disease - therapy; Coronary vessels; Creatine Kinase, MB Form - blood; Creatinine; Creatinine - blood; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - pathology; Diabetes therapy; Diabetics; Disease control; Disease prevention; Double-Blind Method; Endocrinology; Enzymes; Epidermal growth factor receptors; Female; Glomerular Filtration Rate; Heart diseases; Humans; Injury prevention; Intervention; Ischemia; Ischemic Preconditioning; Kidney - blood supply; Kidney diseases; Kidneys; Lipocalin-2 - blood; Male; Medical imaging; Medical research; Medicine; Medicine and Health Sciences; Middle Aged; Nephrology; Neutrophils; Occlusion; Patients; Percutaneous Coronary Intervention; Preconditioning; Prevention; Reperfusion; Signal transduction; Troponin; Troponin T; Troponin T - blood; Type 2 diabetes

Remote ischemic preconditioning (RIPC) induces transient episodes of ischemia by the occlusion of blood flow in non-target tissue, before a subsequent ischemia-reperfusion injury. When RIPC is applied before percutaneous coronary intervention (PCI), the kidneys may be protected against ischemia-repe...