Analysis of immune cell populations in atrial myocardium of patients with atrial fibrillation or sinus rhythm

• Published in: PloS one Vol. 12; no. 2; p. e0172691
• Main Authors: Smorodinova, Natalia, Bláha, Martin, Melenovský, Vojtěch, Rozsívalová, Karolína, Přidal, Jaromír, Ďurišová, Mária, Pirk, Jan, Kautzner, Josef, Kučera, Tomáš
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.02.2017; Public Library of Science (PLoS)
• Subjects: Aged; Arrhythmia; Arrhythmia, Sinus - immunology; Arrhythmia, Sinus - pathology; Arrhythmia, Sinus - physiopathology; Atrial fibrillation; Atrial Fibrillation - immunology; Atrial Fibrillation - pathology; Atrial Fibrillation - physiopathology; B-Lymphocytes - immunology; B-Lymphocytes - pathology; Beta cells; Biology and Life Sciences; Body size; Cardiac arrhythmia; Cardiology; Cardiomyocytes; Cardiomyopathy; Cardiovascular disease; CD20 antigen; CD3 antigen; CD45 antigen; Cell Count; Cell populations; Cell Shape; Coronary vessels; Cytokines; Cytology; DC-SIGN protein; Dendritic cells; Diabetes mellitus; Embryology; Female; Fibrillation; Genetic aspects; Heart Atria - immunology; Heart Atria - pathology; Heart Atria - physiopathology; Heart failure; Heart surgery; Histology; Humans; Hypertension; Immunohistochemistry; Infiltration; Inflammation; Lymphocytes; Lymphocytes T; Macrophages; Male; Markers; Mast cells; Mast Cells - immunology; Mast Cells - pathology; Medicine; Medicine and Health Sciences; Middle Aged; Monocytes; Morphology; Myocardium; Myocardium - immunology; Myocardium - pathology; Pathogenesis; Patients; Populations; Regurgitation; Rhythm; Sinus; Stroke; Studies; Surgery; T cells; T-Lymphocytes - immunology; T-Lymphocytes - pathology; Czech Republic

Atrial fibrillation (AF) is the most common arrhythmia and despite obvious clinical importance remains its pathogenesis only partially explained. A relation between inflammation and AF has been suggested by findings of increased inflammatory markers in AF patients. The goal of this study was to char...