Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997-2012)

• Published in: PloS one Vol. 11; no. 11; p. e0166421
• Main Authors: de Miguel-Díez, Javier, López-de-Andrés, Ana, Jiménez-García, Rodrigo, Puente-Maestu, Luis, Jiménez-Trujillo, Isabel, Hernández-Barrera, Valentín, Resino, Salvador, Álvaro-Meca, Alejandro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.11.2016; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Antiretroviral agents; Antiretroviral therapy; Antiretroviral Therapy, Highly Active; Antiviral Agents - therapeutic use; Biology and Life Sciences; Care and treatment; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Coinfection; Comorbidity; Epidemiology; Female; Health aspects; Hepatitis C virus; Hepatitis C, Chronic - diagnosis; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - epidemiology; Hepatitis C, Chronic - mortality; Highly active antiretroviral therapy; HIV; HIV infections; HIV Infections - diagnosis; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - mortality; HIV patients; Hospital Mortality - trends; Hospitalization - statistics & numerical data; Human immunodeficiency virus; Humans; Incidence; Infection; Lentivirus; Male; Medical research; Medicine and Health Sciences; Middle Aged; Mortality; Patients; People and Places; Preventive medicine; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - mortality; Retrospective Studies; Retroviridae; Spain - epidemiology; Survival Analysis; Trends; United States > US; Spain
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0166421

The aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997-2012). A retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection). 1,580,207 patients discharge with a COPD diagnosis were included in the study, 8902 of them were HIV-infected patients (5000 HIV-monoinfected patients and 3902 HIV/HCV-coinfected patients). The HIV-infected patients had higher incidence rates of hospital admissions for COPD than the HIV-uninfected patients during the study period. The HIV-monoinfected patients had higher rates of hospitalizations for COPD than the HIV/HCV-coinfected patients in the early-period cART (1997-1999), but these rates decreased in the first group and increased in the second, being even similar in both groups in the late-period cART (2004-2011). On the other hand, the HIV-infected patients with COPD had higher IHM than the HIV-uninfected patients with COPD. The mortality rates were higher in the HIV-monoinfected patients with COPD than in the HIV/HCV-coinfected patients with COPD in the early-period cART; however, in the late-period cART, the mortality rates trends seems higher in the HIV/HCV group. The likelihood of death in HIV/HCV-coinfected patients with COPD was similar to than in HIV-monoinfected patients with COPD. Incidence of hospital admissions for COPD and IHM have decreased among HIV-monoinfected individuals but have increased steadily among HIV/HCV-coinfected individuals in the cART era.