Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group

• Published in: Lancet neurology Vol. 20; no. 6; pp. 484 - 496
• Main Authors: Dubois, Bruno, Villain, Nicolas, Frisoni, Giovanni B, Rabinovici, Gil D, Sabbagh, Marwan, Cappa, Stefano, Bejanin, Alexandre, Bombois, Stéphanie, Epelbaum, Stéphane, Teichmann, Marc, Habert, Marie-Odile, Nordberg, Agneta, Blennow, Kaj, Galasko, Douglas, Stern, Yaakov, Rowe, Christopher C, Salloway, Stephen, Schneider, Lon S, Cummings, Jeffrey L, Feldman, Howard H
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2021; Elsevier Limited; Elsevier
• Subjects: Aging; Alzheimer Disease - diagnosis; Alzheimer's disease; Amyloid beta-Peptides - analysis; Amyloid beta-Peptides - metabolism; amyloid-beta; association; Asymptomatic; Biomarkers; Biomarkers - analysis; Cancer; clinicopathological correlations; Cognitive Dysfunction - diagnosis; Dementia; Diagnosis; Disease Progression; Genotype & phenotype; Human health and pathology; Humans; Life Sciences; Medical diagnosis; mild cognitive impairment; national institute; Neurodegeneration; Neurodegenerative diseases; Neuropathology; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; Pathogenesis; Pathology; Phenotype; Phenotypes; risk; Tau protein; tau Proteins - analysis; tau Proteins - metabolism; tau-pet; workgroups; Working groups; United States > US

In 2018, the US National Institute on Aging and the Alzheimer's Association proposed a purely biological definition of Alzheimer's disease that relies on biomarkers. Although the intended use of this framework was for research purposes, it has engendered debate and challenges regarding its...