Role of Interleukin-10 on Nasal Polypogenesis in Patients with Chronic Rhinosinusitis with Nasal Polyps

• Published in: PloS one Vol. 11; no. 9; p. e0161013
• Main Authors: Xu, Jun, Han, Ruining, Kim, Dae Woo, Mo, Ji-Hun, Jin, Yongde, Rha, Ki-Sang, Kim, Yong Min
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2016; Public Library of Science (PLoS)
• Subjects: Adult; Animal models; Animals; Asthma; Autoimmune diseases; Biology and Life Sciences; BLyS protein; Care and treatment; CD19 antigen; Cell activation; Chronic Disease; Complications and side effects; Cytokines; Dendritic cells; Enzyme-linked immunosorbent assay; Female; Flow cytometry; Gene expression; Health aspects; Health risks; Hospitals; Humans; Immunohistochemistry; Inflammation; Interferon; Interleukin 10; Interleukin 5; Interleukin-10 - physiology; Lymphocytes; Lymphocytes B; Male; Medicine; Medicine and Health Sciences; Mice; Mice, Inbred BALB C; Nasal polyps; Nasal Polyps - physiopathology; Nose; Otolaryngology; Pathogenesis; Pathogens; Patients; Polyps; Research and Analysis Methods; Rhinitis; Rhinitis - physiopathology; Rhinosinusitis; Risk factors; Sinusitis; Sinusitis - physiopathology; Surgery; Tissues; Western blotting; Young Adult; γ-Interferon
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0161013

Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. The dysregulation of IL-10 is associated with an enhanced immunopathologic response to infection, as well as with an increased risk for developing numerous autoimmune diseases. In this study, we investigated IL-10 expression in chronic r...