Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease

• Published in: PloS one Vol. 12; no. 1; p. e0167273
• Main Authors: Pan, Xiaoli, Sang, Shaoming, Fei, Guoqiang, Jin, Lirong, Liu, Huimin, Wang, Zhiliang, Wang, Hui, Zhong, Chunjiu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.01.2017; Public Library of Science (PLoS)
• Subjects: Acid Anhydride Hydrolases - blood; Aged; Aged, 80 and over; Aging; Alcohol; Alleles; Alzheimer Disease - blood; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer's disease; Alzheimers disease; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Biology and Life Sciences; Biomarkers; Blood; Blood Glucose; Blood levels; Care and treatment; Case-Control Studies; Chromatography; Chromatography, High Pressure Liquid; Cognitive ability; Collaboration; Dehydrogenases; Dementia; Dementia disorders; Dephosphorylation; Enzymes; Fasting; Female; Genotype; Glucose; Glucose metabolism; Health services; High performance liquid chromatography; Hospitals; Humans; Laboratories; Liquid chromatography; Male; Management; Medical care; Medicine and Health Sciences; Metabolism; Metabolites; Middle Aged; Neurobiology; Neurodegenerative diseases; Neurology; Neurosciences; Patients; Phosphatase; Phosphate esters; Phosphoric Monoester Hydrolases - blood; Phosphorylation; Physical Sciences; Reduction; Research and Analysis Methods; Science; Service centers; Thiamin Pyrophosphokinase - blood; Thiamine; Thiamine - blood; Thiamine diphosphate; Thiamine Monophosphate - blood; Thiamine pyrophosphate; Thyroid gland; Vitamin B

Thiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD). To clarify the mechanism for the reduction of thiamine diphosphate (TDP), an active form of thiamine and critical coenzyme of glucose metabolism, in AD. Forty-five AD patients clinically...