Development of a Korean Fracture Risk Score (KFRS) for Predicting Osteoporotic Fracture Risk: Analysis of Data from the Korean National Health Insurance Service

• Published in: PloS one Vol. 11; no. 7; p. e0158918
• Main Authors: Kim, Ha Young, Jang, Eun Jin, Park, ByeongJu, Kim, Tae-Young, Shin, Soon-Ae, Ha, Yong-Chan, Jang, Sunmee
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2016; Public Library of Science (PLoS)
• Subjects: Aged; Aged, 80 and over; Alcohol; Alcohol use; Alcoholic beverages; Algorithms; Arthritis; Biocompatibility; Biology and Life Sciences; Body mass; Body mass index; Body size; Bone mineral density; Cohort Studies; Cooperation; Data processing; Databases, Factual; Diagnosis; Epidemiology; Female; Fractures; Fractures (Injuries); Fragility; Glucocorticoids; Health insurance; Health risk assessment; Hip joint; Humans; Incidence; Insurance; Insurance, Health; Internal medicine; Male; Mathematical models; Medicine; Medicine and Health Sciences; Methods; Middle Aged; Models, Statistical; Mortality; Older people; Osteoporosis; Osteoporotic Fractures - epidemiology; People and Places; Physical Sciences; Population; Population density; Prediction models; Republic of Korea - epidemiology; Research and Analysis Methods; Rheumatoid arthritis; Risk analysis; Risk assessment; Risk Assessment - methods; Risk Factors; Self-assessment; Smoking; Social Sciences; Studies; Women; South Korea; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0158918

Asian-specific prediction models for estimating individual risk of osteoporotic fractures are rare. We developed a Korean fracture risk prediction model using clinical risk factors and assessed validity of the final model. A total of 718,306 Korean men and women aged 50-90 years were followed for 7 years in a national system-based cohort study. In total, 50% of the subjects were assigned randomly to the development dataset and 50% were assigned to the validation dataset. Clinical risk factors for osteoporotic fracture were assessed at the biennial health check. Data on osteoporotic fractures during the follow-up period were identified by ICD-10 codes and the nationwide database of the National Health Insurance Service (NHIS). During the follow-up period, 19,840 osteoporotic fractures were reported (4,889 in men and 14,951 in women) in the development dataset. The assessment tool called the Korean Fracture Risk Score (KFRS) is comprised of a set of nine variables, including age, body mass index, recent fragility fracture, current smoking, high alcohol intake, lack of regular exercise, recent use of oral glucocorticoid, rheumatoid arthritis, and other causes of secondary osteoporosis. The KFRS predicted osteoporotic fractures over the 7 years. This score was validated using an independent dataset. A close relationship with overall fracture rate was observed when we compared the mean predicted scores after applying the KFRS with the observed risks after 7 years within each 10th of predicted risk. We developed a Korean specific prediction model for osteoporotic fractures. The KFRS was able to predict risk of fracture in the primary population without bone mineral density testing and is therefore suitable for use in both clinical setting and self-assessment. The website is available at http://www.nhis.or.kr.