Investigation of a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population: A Family-Based Study

• Published in: PloS one Vol. 11; no. 8; p. e0160265
• Main Authors: Dong, He, Liu, Wenmiao, Liu, Meixin, Xu, Longqiang, Li, Qiang, Zhang, Ru, Zhang, Xin, Liu, Shiguo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.08.2016; Public Library of Science (PLoS)
• Subjects: Attention deficit hyperactivity disorder; Autism; Biology and Life Sciences; Care and treatment; Child; China - ethnology; Deoxyribonucleic acid; DNA; DNA methylation; DNA nucleotidylexotransferase; Dopamine; Dosage and administration; Ethnic Groups - genetics; Etiology; Family studies; Female; Genes; Genotyping; Genotyping Techniques; Gilles de la Tourette syndrome; Haplotypes; Histidine; Histidine decarboxylase; Histidine Decarboxylase - genetics; Humans; Investigations; Laboratories; Linkage Disequilibrium; Male; Medicine and Health Sciences; Mental disorders; Mutation; Neurosciences; Pedigree; People and places; Physical Sciences; Polymorphism, Single Nucleotide; Population; Population studies; Research and Analysis Methods; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Tourette syndrome; Tourette Syndrome - enzymology; Tourette Syndrome - genetics; Trends
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0160265

Tourette syndrome (TS) is a polygenic neuropsychiatric disease. Previous studies have indicated that dysregulation in the histaminergic system may play a crucial role in disease onset. In this study, we investigated the role of the histidine decarboxylase gene (HDC) in TS susceptibility in the Chinese Han population. After genotyping 241 TS nuclear families trios, we analyzed three tag HDC single nucleotide polymorphisms (rs854150, rs854151, and rs854157) in a family-based study using the transmission disequilibrium test (TDT) and haplotype relative risk (HRR). TDT showed no over-transmission in these SNPs across the HDC region (for rs854150: χ2 = 0.472, P = 0.537, OR = 1.097, 95%CI = 0.738-1.630; for rs854151: χ2 = 0.043, P = 0.889, OR = 1.145, 95%CI = 0.767-1.709; for rs854157:χ2 = 0.984, P = 0.367, OR = 1.020, 95%CI = 0.508-2.049). HRR also showed the same tendency (for rs854150: χ2 = 0.211, P = 0.646, OR = 1.088, 95%CI = 0.759-1.559; for rs854151: χ2 = 0.134, P = 0.714, OR = 0.935, 95%CI = 0.653-1.339; for rs854157:χ2 = 0.841, P = 0.359, OR = 1.206, 95%CI = 0.808-1.799). Additionally, the haplotype-based haplotype relative risk showed a negative association. Although these findings indicate an unlikely association between HDC and TS in the Chinese Han population, a potential role for HDC cannot be ruled out in TS etiology. Future research should investigate this more thoroughly using different populations and larger samples.