Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice

• Published in: PloS one Vol. 11; no. 11; p. e0166342
• Main Authors: Yu, Sung-Hsun, Dubey, Navneet Kumar, Li, Wei-Shan, Liu, Ming-Che, Chiang, Han-Sun, Leu, Sy-Jye, Shieh, Ying-Hua, Tsai, Feng-Chou, Deng, Win-Ping
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.11.2016; Public Library of Science (PLoS)
• Subjects: Adenosine; Alternative medicine; Animals; Antidiabetics; Biological Products - chemistry; Biological Products - therapeutic use; Biology and Life Sciences; Biomedical engineering; Biomedical materials; Blood; Blood glucose; Body weight; Bone morphogenetic proteins; Cholesterol; Collagen; Collagen - analysis; Cordyceps - chemistry; Creatinine; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetic nephropathies; Diabetic Nephropathies - blood; Diabetic Nephropathies - complications; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - physiopathology; Diabetic nephropathy; Drugs; Fibrosis; Fruit bodies; Fruiting Bodies, Fungal - chemistry; Glomerulus; Glucose; Glycation End Products, Advanced - analysis; Glycogen - analysis; Glycosylation; Herbal medicine; Hospitals; Hyperglycemia; Hypoglycemic agents; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - therapeutic use; Immunohistochemistry; Injury prevention; Kidney - drug effects; Kidney - physiopathology; Kidney Function Tests; Laboratory animals; Lipids; Long-term effects; Lysine; Markers; Medical research; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Mycelia; Mycelium - chemistry; Nephrology; Nephropathy; Niacinamide; Nicotinamide; Oxidative stress; Renal function; Research and Analysis Methods; Risk analysis; Risk factors; Rodents; Stem cells; Streptozocin; Tissue engineering; Transforming Growth Factor beta1 - analysis; Transforming growth factor-a; Transplants & implants; Triglycerides; Type 2 diabetes; Urology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0166342

Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN. Hence, this study aimed to further investigate the renal injury-reducing effect of antidiabetic CmNo1, a novel combination of powders of fruiting bodies and mycelia of Cordyceps militaris. After being administered with streptozotocin-nicotinamide and high-fat-diet, the diabetic nephropathy mouse model displayed elevated blood glucose and renal dysfunction markers including serum creatinine and kidney-to-body weight ratio. These elevated markers were significantly mitigated following 8 weeks CmNo1 treatment. Moreover, the chronic hyperglycemia-induced pathological alteration in renal tissue were also ameliorated. Besides, immunohistochemical study demonstrated a substantial reduction in elevated levels of carboxymethyl lysine, an advanced glycation end product. Elevated collagenous deposition in DN group was also attenuated through CmNo1 administration. Moreover, the enhanced levels of transforming growth factor-β1, a fibrosis-inducing protein in glomerulus were also markedly dampened. Furthermore, auxiliary risk factors in DN like serum triglycerides and cholesterol were found to be increased but were decreased by CmNo1 treatment. Conclusively, the results suggests that CmNo1 exhibit potent and efficacious renoprotective action against hyperglycemia-induced DN.