Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction

• Published in: PloS one Vol. 11; no. 11; p. e0166240
• Main Authors: Tabata, Noriaki, Sueta, Daisuke, Akasaka, Tomonori, Arima, Yuichiro, Sakamoto, Kenji, Yamamoto, Eiichiro, Izumiya, Yasuhiro, Yamamuro, Megumi, Tsujita, Kenichi, Kojima, Sunao, Kaikita, Koichi, Morita, Kazunori, Oniki, Kentaro, Saruwatari, Junji, Nakagawa, Kazuko, Hokimoto, Seiji
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.11.2016; Public Library of Science (PLoS)
• Subjects: Acute Coronary Syndrome - complications; Acute Coronary Syndrome - genetics; Acute Coronary Syndrome - virology; Acute coronary syndromes; Aged; Aged, 80 and over; Analysis; Antibodies; Antiulcer agents; Atherosclerosis; Bacterial infections; Biology and Life Sciences; C-reactive protein; C-Reactive Protein - analysis; Cardiology; Cardiovascular disease; Care and treatment; Chlamydia; Confidence intervals; Cytokines; Diabetes; Electrocardiography; Family medical history; Female; Gastric cancer; Genetic aspects; Health aspects; Health risks; Heart attack; Heart attacks; Helicobacter infections; Helicobacter Infections - complications; Helicobacter pylori; Helicobacter pylori - isolation & purification; Hospitals; Humans; Immunoglobulin G; Infection; Infections; Inflammation; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin-1beta - genetics; Interleukins; Male; Medicine; Medicine and Health Sciences; Middle Aged; Myocardial infarction; Patients; Pharmaceutical sciences; Pharmacology; Polymerase chain reaction; Polymorphism; Polymorphism, Genetic; Reclassification; Regression analysis; Risk analysis; Risk Factors; Sensitivity; Single nucleotide polymorphisms; Single-nucleotide polymorphism; ST Elevation Myocardial Infarction - complications; ST Elevation Myocardial Infarction - genetics; ST Elevation Myocardial Infarction - virology; Statistical analysis; Stomach cancer; Studies; Thrombosis; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0166240

Helicobacter pylori infection and interleukin-1 polymorphisms are associated with an increased risk of gastric cancer. We examined the prevalence of Helicobacter pylori seropositivity and interleukin-1 polymorphisms between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome patients. We recruited consecutive acute coronary syndrome patients, and 101 non-ST-segment elevation acute coronary syndrome patients and 103 ST-segment elevation myocardial infarction patients were enrolled. Interleukin-1 polymorphism analyses were performed for single nucleotide polymorphism in interleukin-1 beta-511 and the variable number of tandem repeats polymorphism in the interleukin-1 receptor antagonist by polymerase chain reaction. Immunoglobulin G antibodies against Helicobacter pylori and high sensitivity C-reactive protein were also measured. The rates of the simultaneous presence of interleukin-1 polymorphisms and Helicobacter pylori-seropositivity between non-ST-segment elevation acute coronary syndrome and ST-segment elevation myocardial infarction groups were 25.7% and 42.7%, respectively (P = 0.012). Helicobacter pylori-seropositive subjects with interleukin-1 polymorphisms showed significantly higher levels of high sensitivity C-reactive protein (0.04-0.12 vs. 0.02-0.05; P<0.001). Multivariate logistic regression analysis revealed that the carriage of Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was significantly associated with ST-segment elevation myocardial infarction (odds ratio, 2.32; 95% confidence interval, 1.23-4.37; P = 0.009). The C-statistic of conventional risk factors was 0.68 (P<0.001) and that including Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was 0.70 (P<0.001); continuous net reclassification improvement was 34% (P = 0.0094) and integrated discrimination improvement was 3.0% (P = 0.014). The coincidence of Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was significantly associated with higher levels of high sensitivity C-reactive protein and the increased risk of ST-segment elevation myocardial infarction.