Evolutionary Dynamics of Human Rotaviruses: Balancing Reassortment with Preferred Genome Constellations

• Published in: PLoS pathogens Vol. 5; no. 10; p. e1000634
• Main Authors: McDonald, Sarah M., Matthijnssens, Jelle, McAllen, John K., Hine, Erin, Overton, Larry, Wang, Shiliang, Lemey, Philippe, Zeller, Mark, Van Ranst, Marc, Spiro, David J., Patton, John T.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2009; Public Library of Science (PLoS)
• Subjects: Antigenic Variation - genetics; Child; Child, Preschool; Constellations; Evolution, Molecular; Gastroenteritis; Gastroenteritis - genetics; Gastroenteritis - virology; Genetic aspects; Genetics; Genome, Viral; Genomes; Genotype; Health aspects; Hospitals; Human rotavirus; Human subjects; Humans; Infant; Infections; Models, Molecular; Molecular Sequence Data; Open Reading Frames - genetics; Phylogenetics; Phylogeny; Reassortant Viruses - genetics; Risk factors; Rotavirus; Rotavirus - chemistry; Rotavirus - genetics; Rotavirus Infections - genetics; Rotavirus Infections - virology; Rotaviruses; Seasons; Sequence Analysis, DNA; Viral genetics; Virology/Vaccines; Virology/Virus Evolution and Symbiosis; Viruses; United States

Group A human rotaviruses (RVs) are a major cause of severe gastroenteritis in infants and young children. Yet, aside from the genes encoding serotype antigens (VP7; G-type and VP4; P-type), little is known about the genetic make-up of emerging and endemic human RV strains. To gain insight into the...