Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension

• Published in: Bioscience, biotechnology, and biochemistry Vol. 73; no. 2; pp. 422 - 424
• Main Authors: Saiga Egusa, A.(Nippon Meat Packers Inc., Tsukuba, Ibaraki (Japan). R and D Center), Iwai, K, Hayakawa, T, Takahata, Y, Morimatsu, F
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.02.2009; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: ACTIVIDAD ENZIMATICA; ACTIVITE ENZYMATIQUE; Animals; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Biological and medical sciences; biotechnology; BLOOD PLASMA; blood pressure; Blood Pressure - drug effects; CARDIOVASCULAR AGENTS; chicken collagen hydrolysate; CHICKENS; COLAGENO; COLLAGEN; Collagen - administration & dosage; Collagen - pharmacology; Collagen - therapeutic use; COLLAGENE; endothelial progenitor cell; Endothelium - cytology; ENZYME ACTIVITY; Female; Fundamental and applied biological sciences. Psychology; hematologic tests; HIPERTENSION; Humans; HYDROLYSAT DE PROTEINES; hydrolysates; HYDROLYZED PROTEINS; HYPERTENSION; Hypertension - blood; Hypertension - drug therapy; Hypertension - pathology; Hypertension - physiopathology; Male; MEDICAMENTOS CARDIOVASCULARES; Middle Aged; MODIFICATEUR CARDIOVASCULAIRE; plasma renin activity; PLASMA SANGUIN; PLASMA SANGUINEO; POLLO; POULET; Protein Hydrolysates - administration & dosage; Protein Hydrolysates - pharmacology; Protein Hydrolysates - therapeutic use; PROTEINAS HIDROLIZADAS; RENIN; RENINA; RENINE; stem cells; Stem Cells - cytology; Stem Cells - drug effects; Stem Cells - metabolism; Hypertension; Endothelial cell; plasma renin activity; Enzyme; endothelial progenitor cell; Activation; Peptidases; Vertebrata; Renin; Hydrolysate; Collagen; Hydrolases; Antihypertensive agent; chicken collagen hydrolysate; Aspartic endopeptidases; Chicken; Aves; Progenitor cell
• ISSN: 0916-8451; 1347-6947; 1347-6947
• DOI: 10.1271/bbb.80189

Chicken collagen hydrolysate was given to 15 mildly hypertensive subjects for 4 weeks. Blood pressure was significantly decreased by 11.8 mmHg (P<0.01). A reduction in plasma renin activity was observed in blood test after intake. A colony assay of endothelial progenitor cells in blood samples from non-smokers revealed an approximately 30% increase in the number of colonies.