1 H and 13 C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08)
Abstract A new natural product, named phomopsin A, 1‐(meta‐hydroxyphenyl)‐4‐hydroxy‐3‐isoquinolone (1), together with two known compounds cytochalasin H (2) and glucosylceramide (3), was isolated from the mangrove endophytic fungus Phomopsis sp. (ZZF08) obtained from the South China Sea coast. The s...
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Published in | Magnetic resonance in chemistry Vol. 46; no. 5; pp. 501 - 505 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.05.2008
|
Online Access | Get full text |
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Summary: | Abstract
A new natural product, named phomopsin A, 1‐(meta‐hydroxyphenyl)‐4‐hydroxy‐3‐isoquinolone (1), together with two known compounds cytochalasin H (2) and glucosylceramide (3), was isolated from the mangrove endophytic fungus
Phomopsis
sp. (ZZF08) obtained from the South China Sea coast. The structures were elucidated by 1D and 2D NMR experiments including COSY, HMQC, and HMBC. According to NMR and single‐crystal X‐ray diffraction, it was found that some assignments about
1
H and
13
C NMR data for cytochalasin H (2) were probably uncorrected in the previous reports. In our cytotoxicity assays, compound 1 showed moderate cytotoxicity toward KB cells with IC
50
at 28.0 µg ml
−1
and KBv200 cells with IC
50
at 16.8 µg ml
−1
, and compound 2 exhibited strong cytotoxicity toward KB cells and KBv200 cells with IC
50
less than 1.25 µg ml
−1
. Copyright © 2008 John Wiley & Sons, Ltd. |
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ISSN: | 0749-1581 1097-458X |
DOI: | 10.1002/mrc.2194 |