DNA damage and repair
The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. A...
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| Published in | Nature (London) Vol. 421; no. 6921; pp. 436 - 440 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
23.01.2003
Nature Publishing Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0028-0836 1476-4687 |
| DOI | 10.1038/nature01408 |
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| Abstract | The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution. |
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| AbstractList | The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution. The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution.The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution. |
| Audience | Academic |
| Author | Friedberg, Errol C. |
| Author_xml | – sequence: 1 givenname: Errol C. surname: Friedberg fullname: Friedberg, Errol C. email: friedberg.errol@pathology.swmed.edu organization: Department of Pathology, Laboratory of Molecular Pathology, University of Texas Southwestern Medical Center |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14500061$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12540918$$D View this record in MEDLINE/PubMed |
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| CODEN | NATUAS |
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| Keywords | DNA Review Lesion Mutation Malignant tumor Repair Apoptosis |
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| References | NW Timoféeff-Ressovsky (BFnature01408_CR5) 1935; 1 RB Setlow (BFnature01408_CR16) 1964; 51 B-BS Zhou (BFnature01408_CR21) 2000; 408 A Kelner (BFnature01408_CR9) 1949; 35 BFnature01408_CR8 B Vogelstein (BFnature01408_CR24) 1998 EA De Weerd-Kastelein (BFnature01408_CR26) 1972; 238 A Sancar (BFnature01408_CR28) 1996; 65 T Lindahl (BFnature01408_CR18) 1993; 362 R Parsons (BFnature01408_CR34) 1993; 75 G Levinson (BFnature01408_CR30) 1987; 15 EC Friedberg (BFnature01408_CR11) 1995 KG Zimmer (BFnature01408_CR7) 1992 JD Watson (BFnature01408_CR12) 1953; 171 MF Goodman (BFnature01408_CR20) 2002; 71 T Boveri (BFnature01408_CR23) 1929 EC Friedberg (BFnature01408_CR2) 1997 R Fishel (BFnature01408_CR32) 1993; 75 F Page (BFnature01408_CR19) 2000; 101 G Pontecorvo (BFnature01408_CR4) 1958 HJ Muller (BFnature01408_CR6) 1927; 66 S Cory (BFnature01408_CR22) 2002; 2 RD Wood (BFnature01408_CR27) 1996; 65 R Dulbecco (BFnature01408_CR10) 1949; 162 C Masutani (BFnature01408_CR29) 2000; 65 LA Aaltonen (BFnature01408_CR31) 1993; 260 PC Hanawalt (BFnature01408_CR15) 1967; 216 JD Watson (BFnature01408_CR13) 1968 FS Leach (BFnature01408_CR33) 1993; 75 JE Cleaver (BFnature01408_CR25) 1968; 218 F Crick (BFnature01408_CR1) 1974; 248 JD Watson (BFnature01408_CR14) 1953; 171 EC Friedberg (BFnature01408_CR3) 2002; 1 DE Rasmussen (BFnature01408_CR17) 1964; 203 12569935 - Nature. 2003 Jan 23;421(6921):397-8; discussion 396 4599081 - Nature. 1974 Apr 26;248(5451):766-9 12540917 - Nature. 2003 Jan 23;421(6921):431-5 |
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| SubjectTerms | Biological and medical sciences Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism DNA Damage DNA Repair Evolution feature Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Molecular and cellular biology Molecular biology Molecular genetics multidisciplinary Mutagenesis - genetics Mutagenesis. Repair Mutation Neoplasms - genetics Science Science (multidisciplinary) |
| Title | DNA damage and repair |
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