DNA damage and repair

The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. A...

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Bibliographic Details
Published inNature (London) Vol. 421; no. 6921; pp. 436 - 440
Main Author Friedberg, Errol C.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.01.2003
Nature Publishing
Nature Publishing Group
Subjects
Biological and medical sciences
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA - genetics
DNA - metabolism
DNA Damage
DNA Repair
Evolution
feature
Fundamental and applied biological sciences. Psychology
Humanities and Social Sciences
Molecular and cellular biology
Molecular biology
Molecular genetics
multidisciplinary
Mutagenesis - genetics
Mutagenesis. Repair
Mutation
Neoplasms - genetics
Science
Science (multidisciplinary)
DNA
Review
Lesion
Mutation
Malignant tumor
Repair
Apoptosis
Online AccessGet full text
ISSN0028-0836
1476-4687
DOI10.1038/nature01408

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Summary:The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution.
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ISSN:0028-0836
1476-4687
DOI:10.1038/nature01408