European bone mineral density loci are also associated with BMD in East-Asian populations

• Published in: PloS one Vol. 5; no. 10; p. e13217
• Main Authors: Styrkarsdottir, Unnur, Halldorsson, Bjarni V, Gudbjartsson, Daniel F, Tang, Nelson L S, Koh, Jung-Min, Xiao, Su-mei, Kwok, Timothy C Y, Kim, Ghi Su, Chan, Juliana C N, Cherny, Stacey, Lee, Seung Hun, Kwok, Anthony, Ho, Suzanne, Gretarsdottir, Solveig, Kostic, Jelena Pop, Palsson, Stefan Th, Sigurdsson, Gunnar, Sham, Pak C, Kim, Beom-Jun, Kung, Annie W C, Kim, Shin-Yoon, Woo, Jean, Leung, Ping-C, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.10.2010; Public Library of Science (PLoS)
• Subjects: Aged; Asian Continental Ancestry Group - genetics; Asian people; Bone density; Bone Density - genetics; Bone mineral density; Bone surgery; Chromosome Mapping; Endocrinology; ESR1 protein; Ethnicity; European Continental Ancestry Group - genetics; Female; Gene loci; Genetics; Genetics and Genomics; Genetics and Genomics/Complex Traits; Genetics and Genomics/Gene Discovery; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Population Genetics; Genome-Wide Association Study; Genomes; Genomics; Health care; Hip; Hormone replacement therapy; Hospitals; Humans; Lipoproteins; LRP5 protein; Male; Markers; Medicine; Meta-analysis; Metabolism; Osteoporosis; Osteoprotegerin; Polymorphism, Single Nucleotide; Populations; Proteins; SOST protein; Spine; Studies; Womens health; Hong Kong China; South Korea; United States > US; Iceland
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0013217

Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10(-9)), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10(-5)), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10(-5)), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10(-5)), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians.