Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases

• Published in: Journal of Veterinary Medical Science Vol. 78; no. 6; pp. 1035 - 1038
• Main Authors: FURUSAWA, Takaaki, IWANO, Hidetomo, HIGUCHI, Hidetoshi, YOKOTA, Hiroshi, USUI, Masaru, IWASAKI, Tomohito, TAMURA, Yutaka
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2016; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; antibiotic-resistant bacteria; Bacteria; bacteriophage; Bacteriophages - physiology; Bacteriophages - ultrastructure; Dog Diseases - microbiology; Dog Diseases - virology; Dogs; Drug Resistance, Bacterial; fluoroquinolone; Microscopy, Electron; Pseudomonas aeruginosa; Pseudomonas aeruginosa - virology; Pseudomonas Infections - microbiology; Pseudomonas Infections - veterinary; Pseudomonas Infections - virology; Public Health
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.15-0310

Pseudomonas aeruginosa is a pathogen frequently identified as the cause of diverse infections or chronic disease. This microbe has natural resistance to several kinds of antibiotics, because of the species’ outer membrane, efflux pumps and growth as a biofilm. This bacterium can acquire increased resistance with specific point mutations. Bacteriophage (phage), however, can lyse these bacteria. Therefore, in the present study, we assessed the host range of phages isolates and their ability to lyse antibiotic-resistant P. aeruginosa. Present phages could lyse many strains of P. aeruginosa (28/39), including strains with high resistance to fluoroquinolones (4/6). In conclusion, application of phages for antibiotic-resistant bacteria is greatly effective. To avoid pervasive antibiotic-resistant bacteria, further development of phage usage for disease treatment is required.