Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France

• Published in: Emerging infectious diseases Vol. 26; no. 7; pp. 1529 - 1533
• Main Authors: Beyrouthy, Racha, Dalmasso, Guillaume, Birer, Aurélien, Robin, Frédéric, Bonnet, Richard
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.07.2020; Centers for Disease Control and Prevention
• Subjects: Antibiotics; Antimicrobial agents; antimicrobial resistance; Bacteriology; Biochemistry, Molecular Biology; Dispatch; Drug resistance; France; Genes; Genetic aspects; Genomes; Genotype & phenotype; Health aspects; hypervirulent Klebsiella pneumoniae; Imipenem; Life Sciences; Meropenem; Microbial drug resistance; Microbiology and Parasitology; Molecular biology; Mutation; next-generation sequencing; OXA-48; Oxalic acid; Plasmids; Pneumonia; Sepsis; Tigecycline; Urinary tract diseases; Urinary tract infections; Urogenital system; Virulence; Virulence (Microbiology); β-lactamase; France; Asia; China; bacteria; antimicrobial resistance; next-generation sequencing; hypervirulent; France; OXA-48; β-lactamase; Klebsiella pneumoniae
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2607.191490

We recovered 2 carbapenem-resistant K2-ST86 hypermucoviscous Klebsiella pneumoniae isolates from patients in France. The isolates had genetic attributes of hypervirulent K. pneumoniae but differed in ability to cause mouse lethality. Convergence of hypervirulent K. pneumoniae toward resistance could cause a health crisis because such strains could be responsible for severe and untreatable infections.