Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Methyl-3-substituted Quinazolin-4-(3H)-ones

• Published in: Biological & Pharmaceutical Bulletin Vol. 26; no. 12; pp. 1711 - 1714
• Main Authors: Alagarsamy, Veerachamy, Murugananthan, Gopal, Venkateshperumal, Ramachandran
• Format: Journal Article
• Language: English; Japanese
• Published: Tokyo The Pharmaceutical Society of Japan 01.12.2003; Pharmaceutical Society of Japan; Maruzen; Japan Science and Technology Agency
• Subjects: Administration, Oral; analgesic; Analgesics; Analgesics - chemical synthesis; Analgesics - pharmacology; Analgesics - therapeutic use; Animals; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; anti-inflammatory; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Carrageenan - administration & dosage; Carrageenan - adverse effects; Diclofenac - administration & dosage; Diclofenac - therapeutic use; Disease Models, Animal; Drug Administration Schedule; Female; Foot; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Inflammation - chemically induced; Inflammation - drug therapy; Male; Medical sciences; Microbial Sensitivity Tests - methods; Microbial Sensitivity Tests - standards; Neuropharmacology; Norfloxacin - pharmacology; Norfloxacin - standards; Oxazines - chemical synthesis; Oxazines - pharmacology; Oxazines - therapeutic use; Pain - drug therapy; Pain - prevention & control; Pain Measurement; Pharmacology. Drug treatments; pyrimidine; quinazoline; Quinazolines - chemical synthesis; Quinazolines - pharmacology; Quinazolines - therapeutic use; Rats; Rats, Wistar; thiourea; Time Factors; thiourea; Pharmacological activity; Rat; Quinazoline derivatives; Rodentia; Antiinflammatory agent; Inflammation; In vitro; In vivo; quinazoline; Vertebrata; Chemotherapy; Mammalia; Analgesic; Pain; Treatment; Mouse; Animal; anti-inflammatory; Antibacterial agent; Chemical synthesis; pyrimidine
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.26.1711

A series of novel 2-methyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by treating (2-methyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The compounds synthesized were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds VA2, VA3 and VA4 shown more potent analgesic activity, and the compounds VA3 and VA4 shown more potent anti-inflammatory activity than the reference compound diclofinac sodium.