Genotype Distributions and Allele Frequencies of Possible Major Depressive Disorder-Associated Single Nucleotide Polymorphisms, Cyclic Adenosine Monophosphate Response Element Binding Protein 1 rs4675690 and Piccolo rs2522833, in a Japanese Population

• Published in: Biological & pharmaceutical bulletin Vol. 35; no. 2; pp. 265 - 268
• Main Authors: Suzuki, Eri, Hayashi, Hideki, Tsuji, Daiki, Inoue, Kazuyuki, Ando, Natsuko, Itoh, Kunihiko
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 2012; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Adult; Asian Continental Ancestry Group - genetics; cAMP response element binding protein 1; Cyclic AMP; Cyclic AMP Response Element-Binding Protein - genetics; Cytoskeletal Proteins - genetics; Depression; Depressive Disorder, Major - genetics; Female; Gene Frequency; Gene polymorphism; Genetic factors; Genotype; Humans; Japanese; major depressive disorder; Male; Mental disorders; Middle Aged; Neuropeptides - genetics; Piccolo; polymorphism; Polymorphism, Single Nucleotide; Population genetics; Regulatory sequences; Schizophrenia; Single-nucleotide polymorphism; Young Adult
• ISSN: 0918-6158; 1347-5215; 1347-5215
• DOI: 10.1248/bpb.35.265

It is known that the onset of major depressive disorder (MDD) would be associated with genetic factors. To investigate the susceptibility to psychiatric disorders, e.g. MDD, schizophrenia etc., it is necessary to compare the genetic differences of objective polymorphisms between in patients and in relative contol subjects. Recently, an increasing number of studies focused on the role of cyclic adenosine monophosphate response element binding protein 1 (CREB1) and Piccolo (PCLO) on MDD. However, there was no report about genetic characterization of polymorphisms in between MDD patients and healthy subjects in Japanese population. We analized genotype distributions and allele frequencies of CREB1 rs4675690 and PCLO rs2522833 polymorphisms in 267 Japanese subjects, respectively. In CREB1 rs4675690, C allele frequency (0.41) was lower than T allele (0.59). While in PCLO rs2522833, A allele frequency (0.45) was lower than C allele (0.55). Our findings may be useful for investigating the genetic factors concerning the susceptibility to MDD in Japanese population.