Validation of probabilistic genotyping software for use in forensic DNA casework: Definitions and illustrations

Abstract A number of new computer programs have recently been developed to facilitate the interpretation and statistical weighting of complex DNA profiles in forensic casework. Acceptance of such software in the user community, and subsequent acceptance by the court, relies heavily upon their valida...

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Bibliographic Details
Published inScience & justice Vol. 56; no. 2; pp. 104 - 108
Main Authors Haned, Hinda, Gill, Peter, Lohmueller, Kirk, Inman, Keith, Rudin, Norah
Format Journal Article
LanguageEnglish
Published England Elsevier Ireland Ltd 01.03.2016
Forensic Science Society
Subjects
Deoxyribonucleic acid
DNA
DNA Fingerprinting
Forensic sciences
Genotype
Genotyping
Humans
Likelihood Functions
Likelihood ratio
LRmix
Pathology
Probabilistic
Software
Strength of evidence
Validation
Validation
Likelihood ratio
Strength of evidence
LRmix
Genotyping
Probabilistic
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Summary:Abstract A number of new computer programs have recently been developed to facilitate the interpretation and statistical weighting of complex DNA profiles in forensic casework. Acceptance of such software in the user community, and subsequent acceptance by the court, relies heavily upon their validation. To date, few guidelines exist that describe the appropriate and sufficient validation of such software used in forensic DNA casework. In this paper, we discuss general principles of software validation and how they could be applied to the interpretation software now being introduced into the forensic community. Importantly, we clarify the relationship between a statistical model and its implementation via software. We use the LRmix program to provide specific examples of how these principles can be implemented.
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ISSN:1355-0306
1876-4452
DOI:10.1016/j.scijus.2015.11.007