Prevalence of Congenital Anomalies in the Japan Environment and Children's Study

• Published in: Journal of epidemiology Vol. 29; no. 7; pp. 247 - 256
• Main Authors: Mezawa, Hidetoshi, Tomotaki, Ai, Yamamoto-Hanada, Kiwako, Ishitsuka, Kazue, Ayabe, Tadayuki, Konishi, Mizuho, Saito, Mayako, Yang, Limin, Suganuma, Narufumi, Hirahara, Fumiki, Nakayama, Shoji F, Saito, Hirohisa, Ohya, Yukihiro
• Format: Journal Article
• Language: English
• Published: Japan Japan Epidemiological Association 05.07.2019
• Subjects: Age; birth cohort; Cardiovascular diseases; Children; Cleft lip/palate; Cohort Studies; Congenital Abnormalities - epidemiology; Congenital Abnormalities - ethnology; Congenital anomalies; Congenital defects; Coronary artery disease; Environmental Exposure - adverse effects; Evaluation; Female; Heart diseases; Humans; Infant, Newborn; Infants; Japan - epidemiology; Japan Environment and Children’s Study; JECS; Male; Maternal and Child Health; Medical records; Original; Pregnancy; Prevalence; Prospective Studies; Regional analysis; Risk Factors; Spina bifida; Japan; Japan Environment and Children’s Study; prevalence; JECS; congenital anomalies; birth cohort
• ISSN: 0917-5040; 1349-9092
• DOI: 10.2188/jea.je20180014

The aims of the present report were to estimate the prevalence of congenital anomalies (CAs) among infants in Japan using data from the Japan Environment and Children's Study (JECS) and to evaluate the validity of CA classification within JECS. Data on CAs were collected at delivery and at age 1 month from the medical records of 101,825 infants at 15 regional centers. The analyses focused on 61 CAs, selected on the basis of reported associations with environmental exposure. Prevalence per 10,000 pregnancies (including miscarriages, stillbirths, and live births) was stratified according to four reporting patterns (at delivery, at age 1 month, at either, and at both). To evaluate the accuracy of observed CA prevalence, the medical records of 179 cases from a single JECS regional center underwent independent, retrospective re-evaluation. The prevalence of major CAs in four reporting patterns (at delivery, at age 1 month, at either, and at both) was 2.4, 2.6, 3.5, and 1.4 for myelomeningocele/spina bifida; 4.3, 4.2, 5.3, and 3.2 for cleft palate; 18.1, 17.4, 19.5, and 15.1 for cleft lip with or without cleft palate; 73.4, 100.3, 120.8, and 52.8 for congenital heart disease; and 10.5, 14.1, 15.0, and 9.6 for Down's syndrome, respectively. In the subsample re-evaluation, CA diagnoses were confirmed for 92.7%, 93.3%, 90.5%, and 97.8% of cases in the four reporting patterns (at delivery, at age 1 month, at either, and at both), respectively. The present report generated reliable data concerning the prevalence of major CAs in JECS.