Two New Polyporusterones Isolated from the Sclerotia of Polyporus umbellatus

• Published in: Chemical & Pharmaceutical Bulletin Vol. 55; no. 8; pp. 1148 - 1150
• Main Authors: Zhou, Wei-Wei, Lin, Wen-Han, Guo, Shun-Xing
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 01.08.2007; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Chromatography, High Pressure Liquid; Ergosterol - analogs & derivatives; Ergosterol - chemistry; Ergosterol - isolation & purification; Kinetics; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Molecular Conformation; Pharmacology & Pharmacy; Physical Sciences; Polyporaceae - chemistry; Polyporus; Polyporus umbellatus; polyporusterone; Science & Technology; sclerotia; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; sclerotia; polyporusterone; FRIES; GLUCAN; polyporus umbellatus; PILAT
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.55.1148

In the course of searching for marker components, two new polyporusterones were isolated from the sclerotia of Polyporus umbellatus, together with another three known analogs. The structures of the new ones were elucidated as (20S,22R,24R)-16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one (1) and (23R,24R,25R)-23,26-epoxy-3β,14α,21α,22α-tetrahydroxyergost-7-en-6-one (2) by chemical and spectroscopic means, including HR-FAB-MS, 1D- and 2D-NMR.