Relative telomere length is associated with a functional polymorphism in the monoamine oxidase A gene in a South American sample

• Published in: Journal of genetics Vol. 94; no. 2; pp. 305 - 308
• Main Authors: SPECK-HERNÁNDEZ, CÉSAR A., OJEDA, DIEGO A., CASTRO-VEGA, LUIS J., FORERO, DIEGO A.
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.06.2015; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Animal Genetics and Genomics; Biomedical and Life Sciences; Evolutionary Biology; Female; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genomics; Humans; Life Sciences; Male; Medical colleges; Microbial Genetics and Genomics; Minisatellite Repeats - genetics; Monoamine oxidase; Monoamine Oxidase - genetics; Plant Genetics and Genomics; Polymorphism; Polymorphism, Genetic - genetics; Proteins; Research Note; South America; Telomerase; Telomere Homeostasis - genetics; Telomeres; Young Adult; South America; genetic association; telomeres; Latin America; neuropsychiatric genetics
• ISSN: 0022-1333; 0973-7731
• DOI: 10.1007/s12041-015-0513-1

Human telomeres are nucleoprotein structures at both ends of linear chromosomes and are fundamental for the maintenance of genomic stability and cellular ageing, and for the adequate functioning of cells in the entire human organism (Castro-Vega et al. 2013; Eitan et al. 2014). Telomere length (TL) is increasingly being used as a genomic marker associated with several neuropsychiatric disorders, such as major depression, bipolar disorder, schizophrenia and dementia, among others (Eitan et al. 2014). Regulation of TL is the result of the complex interplay of multiple environmental and genetic factors (Castro-Vega et al. 2013; Eitan et al. 2014).