The Level of Orally Ingested Vitamin C Affected the Expression of Vitamin C Transporters and Vitamin C Accumulation in the Livers of ODS Rats

• Published in: Bioscience, Biotechnology, and Biochemistry Vol. 75; no. 12; pp. 2394 - 2397
• Main Authors: SONE, Yasuko, UETA, Etsuko, KODAMA, Satoru, SANNOUMARU, Yasuko, MIYAKE, Noriko, SONE, Hirohito, FUJIWARA, Yoko, OTSUKA, Yuzuru, KONDO, Kazuo, INAGAKI, Masahiro, NAMBA, Eiji, KURATA, Tadao, SUZUKI, Emiko
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 2011; 日本農芸化学会; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: 2-O-α-D-glucopyranosyl-L-ascorbic acid; Administration, Oral; Animals; ascorbic acid; Ascorbic Acid - administration & dosage; Ascorbic Acid - metabolism; Ascorbic Acid - pharmacology; Biological and medical sciences; biotechnology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - drug effects; Hepatocytes - drug effects; Hepatocytes - metabolism; L-ascorbic acid; Liver - cytology; Liver - drug effects; Liver - metabolism; Male; ODS/ShiJcl-od/od (ODS) rat; Rats; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sodium-Coupled Vitamin C Transporters - genetics; sodium-dependent vitamin C transporter; Ascorbic acid; L-ascorbic acid; Rat; Liver; Rodentia; Vitamin; ODS/ShiJcl-od/od (ODS) rat; 2-O-α-D-glucopyranosyl-L-ascorbic acid; Accumulation; sodium-dependent vitamin C transporter; Vertebrata; Mammalia; Sodium
• ISSN: 0916-8451; 1347-6947; 1347-6947
• DOI: 10.1271/bbb.110312

We investigated the effects of vitamin C administration on vitamin C-specific transporters in ODS/ShiJcl-od/od rat livers. The vitamin C-specific transporter levels increased in the livers of the rats not administered vitamin C and decreased in the livers of those administered vitamin C at 100 mg/d, indicating that these transporter levels can be influenced by the amount of vitamin C administered.