non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

• Published in: European journal of clinical nutrition Vol. 65; no. 2; pp. 175 - 183
• Main Authors: Morisset, M, Aubert-Jacquin, C, Soulaines, P, Moneret-Vautrin, D.A, Dupont, C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2011; Nature Publishing Group
• Subjects: 631/250/249/2510/9; 631/326/171/1495; 692/700/1720; Age; Allergens; Allergies; Allergy in children; Atopy; Babies; Baby foods; Bifidobacterium - growth & development; Bifidobacterium - physiology; Bifidobacterium breve; Biological and medical sciences; Birth; Children; Clinical Nutrition; Clinical trials; Cow's milk; Cultured Milk Products - immunology; Cultured Milk Products - microbiology; Diet; Digestive System Diseases - epidemiology; Digestive System Diseases - prevention & control; Double-Blind Method; Epidemiology; Feeding. Feeding behavior; Female; Fermentation; Fermented milk; Fermented milk products; Food; Food allergies; Food Hypersensitivity - epidemiology; Food Hypersensitivity - prevention & control; Fundamental and applied biological sciences. Psychology; Genetics; Health aspects; Humans; Hypersensitivity; Hypersensitivity, Immediate - epidemiology; Hypersensitivity, Immediate - prevention & control; Immunoglobulin E; Infant; Infant Food; Infant Formula - administration & dosage; Infant formulas; Infant, Newborn; Infants; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Milk; milk allergy; Milk Hypersensitivity - prevention & control; Nutrition research; original-article; Patch tests; Probiotics; Probiotics - administration & dosage; Public Health; Respiratory Tract Diseases - epidemiology; Respiratory Tract Diseases - prevention & control; Risk; Risk factors; Side effects; Skin; Skin tests; Streptococcus thermophilus; Streptococcus thermophilus - growth & development; Streptococcus thermophilus - physiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; France; cow's milk allergy; fermented infant formula; prebiotic; family history of atopy; Allergy; High risk; Infant; History; Atopy; Actinomycetales; Family environment; Bacteria; Micrococcales; Infant formula; Cultured milk; Human; Immunopathology; Streptococcus thermophilus; Actinomycetaceae; Digestive system; Family study; Bifidobacterium breve; Metabolic diseases; Streptococcaceae; Streptococcus salivarius subsp. thermophilus; Cow milk; Actinomycetes; Prebiotic; Fermented infant formula
• ISSN: 0954-3007; 1476-5640; 1476-5640
• DOI: 10.1038/ejcn.2010.250

Background/Objectives: To determine the impact of a not hydrolyzed fermented infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus thermophilus 065 (HKBBST) on the incidence of allergy-like events during the first 2 years of life in children at high risk of atopy. Subjects/Methods: This multicenter, randomized, double-blind, controlled study included infants at high risk of atopy. Infants used HKBBST or a standard infant formula (SIF) since birth until 1 year of age, and were followed at 4, 12 and 24 months after birth. Skin prick tests (SPTs) for six foods and six aeroallergens were systematically performed and adverse events (AEs) were recorded. In case of potentially allergic AE (PAAE), allergy could be further tested by SPT, patch tests and quantification of specific IgEs. If cow's milk allergy (CMA) was suspected, an oral challenge could also be performed. Results: The study included 129 children, 63 were randomized to SIF, 66 to HKBBST. The use of HKBBST milk did not alter the proportion of CMA but decreased the proportion of positive SPT to cow's milk (1.7 vs 12.5%, P=0.03), and the incidence of digestive (39 vs 63%, P=0.01) and respiratory potentially allergic AEs (7 vs 21%, P=0.03) at 12 months, and that of respiratory PAAEs at 24 months (13 vs 35%, P=0.01). Conclusions: HKBBST decreased the incidence of PAAEs in children with family history of atopy, during the first months of life and after the formula was stopped. Oral tolerance to cow's milk in infants at high risk of atopy may therefore be improved using not hydrolyzed fermented formulae.