Season of Birth and Dopamine Receptor Gene Associations with Impulsivity, Sensation Seeking and Reproductive Behaviors

• Published in: PloS one Vol. 2; no. 11; p. e1216
• Main Authors: Eisenberg, Dan T. A., Campbell, Benjamin, MacKillop, James, Lum, J. Koji, Wilson, David S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.11.2007; Public Library of Science (PLoS)
• Subjects: Adult; Age; Analysis; Behavior; Biology; Birth; Blood pressure; Brain research; Childbirth & labor; Developmental Biology/Neurodevelopment; Dopamine; Dopamine D2 receptors; Dopamine D4 receptors; Dopamine receptors; Eating disorders; Evolutionary Biology/Human Evolution; Evolutionary Biology/Sexual Behavior; Experimental psychology; Gender; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetics and Genomics; Genotypes; Health aspects; Humans; Hypotheses; Impulsive behavior; Impulsive Behavior - genetics; Impulsivity; Independent variables; Kinases; Laboratories; Males; Mathematical models; Melatonin; Minisatellite Repeats; Neuroscience; Neuroscience/Behavioral Neuroscience; Neuroscience/Neurodevelopment; Parturition; Phenols (Class of compounds); Phenotype; Physiological aspects; Physiology; Polymorphism; Polymorphism, Genetic; Psychology; Receptors, Dopamine - genetics; Regression analysis; Regression models; Reproduction - physiology; Rodents; Schizophrenia; Seasons; Secondary analysis; Sensation - physiology; Surveys and Questionnaires; Winter; New York; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0001216

Season of birth (SOB) has been associated with many physiological and psychological traits including novelty seeking and sensation seeking. Similar traits have been associated with genetic polymorphisms in the dopamine system. SOB and dopamine receptor genetic polymorphisms may independently and interactively influence similar behaviors through their common effects on the dopaminergic system. Based on a sample of 195 subjects, we examined whether SOB was associated with impulsivity, sensation seeking and reproductive behaviors. Additionally we examined potential interactions of dopamine receptor genes with SOB for the same set of traits. Phenotypes were evaluated using the Sociosexual Orientation Inventory, the Barratt Impulsivity Scale, the Eysenck Impulsivity Questionnaire, the Sensation Seeking Scale, and the Delay Discounting Task. Subjects were also asked about their age at first sex as well as their desired age at the birth of their first child. The dopamine gene polymorphisms examined were Dopamine Receptor D2 (DRD2) TaqI A and D4 (DRD4) 48 bp VNTR. Primary analyses included factorial genderxSOB ANOVAs or binary logistic regression models for each dependent trait. Secondary analysis extended the factorial models by also including DRD2 and DRD4 genotypes as independent variables. Winter-born males were more sensation seeking than non-winter born males. In factorial models including both genotype and season of birth as variables, two previously unobserved effects were discovered: (1) a SOBxDRD4 interaction effect on venturesomeness and (2) a DRD2xDRD4 interaction effect on sensation seeking. These results are consistent with past findings that SOB is related to sensation seeking. Additionally, these results provide tentative support for the hypothesis that SOB modifies the behavioral expression of dopaminergic genetic polymorphism. These findings suggest that SOB should be included in future studies of risky behaviors and behavioral genetic studies of the dopamine system.