Flat Serrated Adenomas and Flat Tubular Adenomas of the Colorectal Mucosa: Differences in the Pattern of Cell Proliferation

• Published in: Cancer science Vol. 86; no. 8; pp. 756 - 760
• Main Authors: Rubio, Carlos A., Rodensjö, Margareta
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.1995; Japanese Cancer Association; John Wiley & Sons, Inc
• Subjects: Adenocarcinoma; Adenoma - pathology; Antibodies, Monoclonal; Antigens, Neoplasm - analysis; Biological and medical sciences; Biomarkers, Tumor - analysis; Cell Division - physiology; Cell growth; Cell proliferation; Colorectal mucosa; Colorectal Neoplasms - pathology; Female; Flat neoplasia; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Intestinal Mucosa - pathology; Invasiveness; Kinases; Male; Medical sciences; Medicin och hälsovetenskap; Monoclonal antibodies; Mucosa; Serrated adenoma; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Immunohistochemistry; Cell proliferation; Flat shape; Morphology; Rectum; Digestive diseases; Intestinal disease; Exploration; Benign neoplasm; Adenoma; Colon
• ISSN: 0910-5050; 1347-9032; 1349-7006; 1876-4673
• DOI: 10.1111/j.1349-7006.1995.tb02465.x

In the present work we have investigated the cell proliferation pattern of flat serrated adenomas and flat tubular adenomas. For this purpose tissue sections from 23 consecutive flat serrated adenomas and 22 consecutive flat tubular adenomas of the colorcctal mucosa were challenged with MID1, a monoclonal antibody directed against a proliferation‐related antigen. The results (including semi‐quantitative studies) demonstrated that, whereas flat serrated adenomas had a high cell proliferation at the lower part of the crypts, flat tubular adenomas had a high cell proliferation in the upper part of the crypts. In serrated adenomas with invasive adenocarcinoma, high cell proliferation was demonstrated both at the lower portion of the crypts and in the subjacent submucosa. This suggests that the cells of the lower portion of the crypts in serrated adenomas are truely neoplastic, with the capacity to evolve into invasive growth. The difference in cell proliferation betweeen the two types of flat lesions reported here is a new argument in favor of the classification of flat serrated adenomas as a novel and independent type of neoplastic change of the colorectal mucosa.