Independent Control of Topography for 3D Patterning of the ECM Microenvironment

• Published in: Advanced materials (Weinheim) Vol. 28; no. 1; pp. 132 - 137
• Main Authors: Kim, Jiyun, Staunton, Jack Rory, Tanner, Kandice
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 06.01.2016; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Subjects: 3D biomaterials; Animals; Anisotropy; Beads; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; biomimetic extracellular matrix; Biomimetics; Cell Proliferation - drug effects; Cellular Microenvironment - drug effects; Communication; Communications; Electrochemical machining; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; extracellular matrix topography; Magnetic Fields; magnetic-field-directed self-assembly; Mice; NIH 3T3 Cells; Patterning; PC12 Cells; Rats; Self assembly; Three dimensional; Tissue Scaffolds - chemistry; Topography; biomimetic extracellular matrix; extracellular matrix topography; 3D biomaterials; magnetic-field-directed self-assembly
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201503950

Biomimetic extracellular matrix (ECM) topographies driven by the magnetic‐field‐directed self‐assembly of ECM protein‐coated magnetic beads are fabricated. This novel bottom‐up method allows us to program isotropic, anisotropic, and diverse hybrid ECM patterns without changing other physicochemical properties of the scaffold material. It is demonstrated that this 3D anisotropic matrix is able to guide the dendritic protrusion of cells.